[Microcirculatory disorders in the early period of autotoxic shock].

Microcirculation in the rat mesenterium was studied in the early period of autotoxic shock, using light and electron microscopy. Progressive reduction in the number of functioning capillaries, blood flow slowing in microvessels, and increase in the number of leukocytes that adhere to the luminal surface of the endothelium have been noted. Cases of stasis, sludge syndrome, thrombosis of small venules and disturbances of vascular permeability for protein have been observed. Ultrastructural changes: the formation of transendothelial canals and destructive changes in the basal membrane testify to the disturbance of the barrier function in microvessels. The role of free radicals in the pathogenesis of autotoxic shock is discussed.