Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
Section of Cardiology, San Francisco Veterans Affairs Medical Center and School of Medicine, University of California San Francisco, San Francisco, CA, USA.
Eur J Heart Fail. 2021 Apr;23(4):541-551. doi: 10.1002/ejhf.2125. Epub 2021 Mar 23.
Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET.
左心室射血时间（LVET）定义为主动脉瓣开放到主动脉瓣关闭的时间间隔，是左心室将血液喷射到主动脉的收缩期阶段。几十年来，LVET 一直被用于评估左心室功能和收缩性。然而，最近人们对 LVET 作为心力衰竭射血分数降低（HFrEF）患者新型药物治疗作用的衡量指标产生了兴趣，因为这些患者的 LVET 缩短。本综述提供了关于 LVET 的可用信息概述，包括测量 LVET 的方法、对 LVET 的机械理解、LVET 与结局的关系、HFrEF 中 LVET 缩短的背后机制以及影响和使 LVET 正常化的药物的潜在意义。
