文献检索文档翻译深度研究
Suppr Zotero 插件Zotero 插件
邀请有礼套餐&价格历史记录

新学期，新优惠

限时优惠:9月1日-9月22日

30天高级会员仅需29元

1天体验卡首发特惠仅需5.99元

了解详情
不再提醒
插件&应用
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
高级版
套餐订阅购买积分包
AI 工具
文献检索文档翻译深度研究
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2025

三种主要的短链脂肪酸可抑制肺炎支原体激活 THP-1 细胞。

Three main short-chain fatty acids inhibit the activation of THP-1 cells by Mycoplasma pneumoniae.

机构信息

School of Medicine, Jiangsu University, Zhenjiang, China.

School of Medical Technology, Zhenjiang College, Zhenjiang, China.

出版信息

Biosci Biotechnol Biochem. 2021 Mar 24;85(4):923-930. doi: 10.1093/bbb/zbaa110.

DOI:10.1093/bbb/zbaa110
PMID:33590852
Abstract

The overactivation of macrophages causes chronic inflammatory diseases. Short-chain fatty acids (SCFAs), potential drugs for clinical treatment, are modulators of macrophage inflammatory reaction. Therefore, the modulation of macrophage-mediated cell activity is expected to become a new therapeutic strategy for inflammatory diseases caused by Mycoplasma pneumoniae. In this study, 2 kinds of SCFAs (propionate and butyrate) were found to have anti-inflammatory effects in M. pneumoniae-stimulated THP-1 cells inflammatory. They inhibited the expressions of IL-4, IL-6, ROS, and NLRP3 inflammasome, while enhancing the expressions of IL-10 and IFN-γ. Our study revealed these 2 agents to repress transcriptional activities of NF-κB, which are important modulators of inflammation. Meanwhile, SCFAs can significantly enhance the autophagy induced by M. pneumoniae. Considering that SCFAs have few side effects, they might be the promising adjuvant therapy for the prevention and/or treatment of various inflammatory diseases.

摘要

巨噬细胞的过度激活会导致慢性炎症性疾病。短链脂肪酸（SCFAs）是一种有临床应用潜力的药物，可调节巨噬细胞炎症反应。因此，调节巨噬细胞介导的细胞活性有望成为一种治疗肺炎支原体引起的炎症性疾病的新策略。在这项研究中，发现 2 种 SCFAs（丙酸和丁酸）对肺炎支原体刺激的 THP-1 细胞炎症具有抗炎作用。它们抑制了 IL-4、IL-6、ROS 和 NLRP3 炎性体的表达，同时增强了 IL-10 和 IFN-γ的表达。我们的研究表明，这两种物质可以抑制 NF-κB 的转录活性，NF-κB 是炎症的重要调节因子。同时，SCFAs 可显著增强肺炎支原体诱导的自噬。鉴于 SCFAs 副作用较小，它们可能是预防和/或治疗各种炎症性疾病的有前途的辅助治疗药物。

相似文献

[1]
Three main short-chain fatty acids inhibit the activation of THP-1 cells by Mycoplasma pneumoniae.

Biosci Biotechnol Biochem. 2021-3-24

[2]
Short-Chain Fatty Acids Attenuate 5-Fluorouracil-Induced THP-1 Cell Inflammation through Inhibiting NF-κB/NLRP3 Signaling via Glycerolphospholipid and Sphingolipid Metabolism.

Molecules. 2023-1-4

[3]
Short-Chain Fatty Acids Manifest Stimulative and Protective Effects on Intestinal Barrier Function Through the Inhibition of NLRP3 Inflammasome and Autophagy.

Cell Physiol Biochem. 2018

[4]
Anti-inflammatory effects of NaB and NaPc in -stimulated THP-1 cells TLR-2/NF-κB/ROS/NLRP3 pathway.

Acta Pharm. 2022-10-18

[5]
Three important short-chain fatty acids (SCFAs) attenuate the inflammatory response induced by 5-FU and maintain the integrity of intestinal mucosal tight junction.

BMC Immunol. 2022-4-21

[6]
SCFAs promote intestinal double-negative T cells to regulate the inflammatory response mediated by NLRP3 inflammasome.

Aging (Albany NY). 2021-9-7

[7]
Short-Chain Fatty Acids Weaken Ox-LDL-Induced Cell Inflammatory Injury by Inhibiting the NLRP3/Caspase-1 Pathway and Affecting Cellular Metabolism in THP-1 Cells.

Molecules. 2022-12-12

[8]
Differential effects of short chain fatty acids on endothelial Nlrp3 inflammasome activation and neointima formation: Antioxidant action of butyrate.

Redox Biol. 2018-2-13

[9]
Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels.

Eur J Med Res. 2024-4-15

[10]
NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.

Infect Immun. 2017-12-19

引用本文的文献

[1]
Liubao Tea Extract Attenuates High-Fat Diet and Streptozotocin-Induced Type 2 Diabetes in Mice by Remodeling Hepatic Metabolism and Gut Microbiota.

Nutrients. 2025-8-18

[2]
, , and Acids as Potential TNF Modulators: An Integrated Study Combining Molecular Docking, Dynamics Simulations, ADMET Profiling, and Gene Expression Analysis.

Molecules. 2025-7-29

[3]
High-Calorie Diets Exacerbate Lipopolysaccharide-Induced Pneumonia by Promoting Propionate-Mediated Neutrophil Extracellular Traps.

Nutrients. 2025-7-7

[4]
The Role of Inactivation Methods in Shaping Postbiotic Composition and Modulating Bioactivity: A Review.

Foods. 2025-7-2

[5]
Advances in gut-lung axis research: clinical perspectives on pneumonia prevention and treatment.

Front Immunol. 2025-4-22

[6]
Capsaicin Modulates Hepatic and Intestinal Inflammation and Oxidative Stress by Regulating the Colon Microbiota.

Antioxidants (Basel). 2024-8-2

[7]
Gut-Derived Short-Chain Fatty Acids and Macrophage Modulation: Exploring Therapeutic Potentials in Pulmonary Fungal Infections.

Clin Rev Allergy Immunol. 2024-6

[8]
The Influence of Probiotic Supplementation on the Obesity Indexes, Neuroinflammatory and Oxidative Stress Markers, Gut Microbial Diversity, and Working Memory in Obese Thai Children.

Foods. 2023-10-24

[9]
Short-Chain Fatty Acids Attenuate 5-Fluorouracil-Induced THP-1 Cell Inflammation through Inhibiting NF-κB/NLRP3 Signaling via Glycerolphospholipid and Sphingolipid Metabolism.

Molecules. 2023-1-4

[10]
Health Benefits and Side Effects of Short-Chain Fatty Acids.

Foods. 2022-9-15

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

推荐工具

医学文档翻译智能文献检索