Pharmacological Research Center of Medicinal Plants, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Pharmaceutical Sciences in Persian Medicine, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Phytother Res. 2021 Jul;35(7):3558-3574. doi: 10.1002/ptr.7046. Epub 2021 Feb 16.
Metabolic syndrome is known as a group of metabolic abnormalities with features including central obesity, insulin resistance, hypercholesterolemia, hypertriglyceridemia, and hypertension as well as low level of high-density lipoprotein (HDL)-cholesterol. Previous studies showed the ameliorating effects of Scutellaria baicalensis on metabolic syndrome parameters, including antidiabetic, anti-hyperlipidemic, anti-obesity, and antihypertensive. In this review, we deeply and mechanistically evaluated different studies on the effect of S. baicalensis and its two major bioactive constituents, baicalin, and baicalein, on the critical components of metabolic syndrome, including diabetes, hyperlipidemia, obesity, hypertension, and atherosclerosis. Scientific databases, including PubMed, Scopus, and Google Scholar were searched in the English language until the end of June 2020. Accordingly, S. baicalensis, and its two major bioactive constituents, baicalin and baicalein, represent promising effects on the control of metabolic syndrome and its related disorders such as obesity, hyperlipidemia, atherosclerosis, diabetes, and their following complications. In summary, our findings show that S. baicalensis and its active constituents, baicalin and baicalein, by activation and upregulation of AMPK and PPAR-γ as the main signaling in the hemostasis of glucose and lipid metabolisms may be favorable candidates for the prevention and treatment of the metabolic syndrome.
代谢综合征是一组代谢异常的疾病，其特征包括中心性肥胖、胰岛素抵抗、高胆固醇血症、高三酰甘油血症、高血压以及低水平高密度脂蛋白（HDL）胆固醇。先前的研究表明，黄芩对代谢综合征参数具有改善作用，包括降血糖、降血脂、抗肥胖和降血压。在这篇综述中，我们深入和机制地评估了不同的研究，关于黄芩及其两种主要生物活性成分黄芩苷和黄芩素对代谢综合征关键成分的影响，包括糖尿病、高脂血症、肥胖、高血压和动脉粥样硬化。以英文语言在科学数据库，包括 PubMed、Scopus 和 Google Scholar 中进行搜索，直至 2020 年 6 月底。因此，黄芩及其两种主要生物活性成分黄芩苷和黄芩素，对控制代谢综合征及其相关疾病，如肥胖、高脂血症、动脉粥样硬化、糖尿病及其后续并发症，具有潜在的有益作用。总之，我们的研究结果表明，黄芩及其活性成分黄芩苷和黄芩素通过激活和上调 AMPK 和 PPAR-γ 作为血糖和脂质代谢稳态的主要信号，可能是预防和治疗代谢综合征的候选药物。
