Shandong University of Traditional Chinese Medicine, College of Traditional Chinese Medicine, Jinan 250014, China.
Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Peripheral Vascular Disease, Jinan 250014, China.
Biomed Pharmacother. 2022 Apr;148:112690. doi: 10.1016/j.biopha.2022.112690. Epub 2022 Feb 11.
Diabetes mellitus is a common disorder of endocrine and metabolic disorders. Long term hyperglycemia can lead to a variety of serious chronic complications, such as diabetic nephropathy, diabetic retinopathy, diabetes cardiovascular disease, and so on, threatening human life, health and safety. Scutellaria baicalensis Georgi is one of the most commonly used traditional Chinese medicine. Flavonoids are the main effective components of Scutellaria baicalensis Georgi. The flavonoids are mainly baicalin, baicalein, wogonoside and wogonin. The four have the effects of improving the renal function, insulin resistance and retinopathy of type 2 diabetic patients. The aim of this review is to summarize the pathogenesis and clinical research progress of baicalin, baicalein, wogonoside and wogonin in Scutellaria baicalensis Georgi in the treatment of type 2 diabetes mellitus and its complications.
糖尿病是一种常见的内分泌和代谢紊乱疾病。长期的高血糖会导致多种严重的慢性并发症，如糖尿病肾病、糖尿病视网膜病变、糖尿病心血管疾病等，威胁着人类的生命、健康和安全。黄芩是最常用的中药之一。黄酮类化合物是黄芩的主要有效成分。黄酮类化合物主要有黄芩苷、黄芩素、汉黄芩苷和汉黄芩素。这四种成分具有改善肾功能、胰岛素抵抗和 2 型糖尿病患者视网膜病变的作用。本综述的目的是总结黄芩中黄芩苷、黄芩素、汉黄芩苷和汉黄芩素在治疗 2 型糖尿病及其并发症中的作用机制和临床研究进展。
