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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Chowdrey H S, Bisset G W

Medical Unit, Westminster Hospital, London.

Br J Pharmacol. 1988 Feb;93(2):349-56. doi: 10.1111/j.1476-5381.1988.tb11441.x.

gamma-Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.) in the water-loaded rat under ethanol anaesthesia. 2. The inhibitory effect of GABA was mimicked by muscimol and 3-amino-1-propane sulphonic acid (3-APS) and blocked by bicuculline. 3. GABA injected i.v. or into the cisterna magna (i.cist.) did not inhibit the release of vasopressin by carbachol injected i.c.v. 4. The results suggest a role for GABA as a putative inhibitory transmitter in the hypothalamo-neurohypophysial system, acting directly on the supraoptic or paraventricular nuclei in the anterior hypothalamus.

在乙醇麻醉下给饮水负荷的大鼠侧脑室注射γ-氨基丁酸（GABA）和卡巴胆碱时，GABA抑制了抗利尿反应以及卡巴胆碱引起的抗利尿激素尿排泄增加。2. 蝇蕈醇和3-氨基-1-丙烷磺酸（3-APS）模拟了GABA的抑制作用，而荷包牡丹碱则阻断了这种作用。3. 静脉注射或蛛网膜下腔注射GABA不抑制侧脑室注射卡巴胆碱引起的抗利尿激素释放。4. 这些结果表明，GABA可能作为下丘脑-神经垂体系统中的一种抑制性递质，直接作用于下丘脑前部的视上核或室旁核。

Chowdrey H S, Bisset G W

Medical Unit, Westminster Hospital, London.

Br J Pharmacol. 1988 Feb;93(2):349-56. doi: 10.1111/j.1476-5381.1988.tb11441.x.

gamma-Aminobutyric acid (GABA) inhibited the antidiuretic response and the increased urinary excretion of vasopressin produced by carbachol when both drugs were injected into a lateral cerebral ventricle (i.c.v.) in the water-loaded rat under ethanol anaesthesia. 2. The inhibitory effect of GABA was mimicked by muscimol and 3-amino-1-propane sulphonic acid (3-APS) and blocked by bicuculline. 3. GABA injected i.v. or into the cisterna magna (i.cist.) did not inhibit the release of vasopressin by carbachol injected i.c.v. 4. The results suggest a role for GABA as a putative inhibitory transmitter in the hypothalamo-neurohypophysial system, acting directly on the supraoptic or paraventricular nuclei in the anterior hypothalamus.

在乙醇麻醉下给饮水负荷的大鼠侧脑室注射γ-氨基丁酸（GABA）和卡巴胆碱时，GABA抑制了抗利尿反应以及卡巴胆碱引起的抗利尿激素尿排泄增加。2. 蝇蕈醇和3-氨基-1-丙烷磺酸（3-APS）模拟了GABA的抑制作用，而荷包牡丹碱则阻断了这种作用。3. 静脉注射或蛛网膜下腔注射GABA不抑制侧脑室注射卡巴胆碱引起的抗利尿激素释放。4. 这些结果表明，GABA可能作为下丘脑-神经垂体系统中的一种抑制性递质，直接作用于下丘脑前部的视上核或室旁核。