溶血磷脂酰胆碱诱导的心律失常及其在大鼠离体灌流心脏中的蓄积
Lysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart.
作者信息
Man R Y
机构信息
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Manitoba, Winnipeg, Canada.
出版信息
Br J Pharmacol. 1988 Feb;93(2):412-6. doi: 10.1111/j.1476-5381.1988.tb11448.x.
Abstract
- The tissue level of lysophosphatidylcholine (LPC) was determined in rat hearts perfused with a solution containing 5 microM LPC. The relationship between LPC accumulation and the severity of arrhythmias produced was examined. 2. The accumulation of LPC was dependent on the perfusion time and this accumulation was associated with the occurrence of severe arrhythmias. A positive correlation between the tissue LPC content and the arrhythmia score was found (P less than 0.01). 3. No consistent alteration in total phospholipid, phosphatidylcholine or cholesterol content was found. This suggests that LPC-induced arrhythmias are not associated with alterations of major lipid components in the heart. 4. When severe arrhythmias occurred in the presence of LPC in the rat perfused heart, less than 2% of total tissue phospholipid was in the form of LPC. 5. The positive correlation between LPC accumulation and the occurrence of arrhythmias suggests a cause and effect relationship of LPC with cardiac arrhythmias in the rat perfused heart. However, in the ischaemic heart, other biochemical factors can contribute, to different degrees, to ischaemia-induced cardiac arrhythmias.
摘要
- 测定了用含5微摩尔溶血磷脂酰胆碱（LPC）的溶液灌注的大鼠心脏中LPC的组织水平。研究了LPC蓄积与所产生的心律失常严重程度之间的关系。2. LPC的蓄积取决于灌注时间，且这种蓄积与严重心律失常的发生有关。发现组织LPC含量与心律失常评分之间呈正相关（P<0.01）。3. 未发现总磷脂、磷脂酰胆碱或胆固醇含量有一致的变化。这表明LPC诱导的心律失常与心脏主要脂质成分的改变无关。4. 当在灌注的大鼠心脏中LPC存在时发生严重心律失常时，总组织磷脂中以LPC形式存在的不到2%。5. LPC蓄积与心律失常发生之间的正相关表明在灌注的大鼠心脏中LPC与心律失常之间存在因果关系。然而，在缺血心脏中，其他生化因素可不同程度地促成缺血诱导的心律失常。
相似文献
1
Lysophosphatidylcholine-induced arrhythmias and its accumulation in the rat perfused heart.溶血磷脂酰胆碱诱导的心律失常及其在大鼠离体灌流心脏中的蓄积
Br J Pharmacol. 1988 Feb;93(2):412-6. doi: 10.1111/j.1476-5381.1988.tb11448.x.
2
Lysophosphatidylcholine metabolism and cardiac arrhythmias.溶血磷脂酰胆碱代谢与心律失常
Can J Physiol Pharmacol. 1988 Mar;66(3):185-9. doi: 10.1139/y88-032.
3
Effect of reduced calcium on lysophosphatidylcholine-induced cardiac arrhythmias.钙含量降低对溶血磷脂酰胆碱诱导的心律失常的影响。
Pharmacology. 1985;31(1):11-6. doi: 10.1159/000138092.
4
Lysophosphatidylcholine accumulation in the ischemic canine heart.
Lipids. 1988 Jan;23(1):32-5. doi: 10.1007/BF02535301.
5
Phosphatidylcholine metabolism in isolated rat heart: modulation by ethanol and vitamin E.离体大鼠心脏中的磷脂酰胆碱代谢：乙醇和维生素E的调节作用
Biochim Biophys Acta. 1989 Oct 17;1005(3):225-32. doi: 10.1016/0005-2760(89)90041-6.
6
Origin of plasma lysophosphatidylcholine: evidence for direct hepatic secretion in the rat.血浆溶血磷脂酰胆碱的来源：大鼠肝脏直接分泌的证据。
J Lab Clin Med. 1985 Feb;105(2):190-4.
7
A new approach to the development of anti-ischemic drugs. Substances that counteract the deleterious effect of lysophosphatidylcholine on the heart.一种开发抗缺血药物的新方法。对抗溶血磷脂酰胆碱对心脏有害作用的物质。
Jpn Heart J. 1997 Jan;38(1):11-25. doi: 10.1536/ihj.38.11.
8
Magnesium antagonizes the actions of lysophosphatidyl choline (LPC) in myocardial cells: a possible mechanism for its antiarrhythmic effects.镁拮抗心肌细胞中溶血磷脂酰胆碱（LPC）的作用：其抗心律失常作用的一种可能机制。
Anesth Analg. 1995 Jun;80(6):1083-7. doi: 10.1097/00000539-199506000-00003.
9
Effects of endogenous and exogenous lysophosphatidylcholine in isolated perfused rat hearts.内源性和外源性溶血磷脂酰胆碱对离体灌注大鼠心脏的影响。
J Mol Cell Cardiol. 1993 Aug;25(8):905-13. doi: 10.1006/jmcc.1993.1103.
10
A study on dilazep: II. Dilazep attenuates lysophosphatidylcholine-induced mechanical and metabolic derangements in the isolated, working rat heart.双嘧达莫的研究：II. 双嘧达莫减轻溶血磷脂酰胆碱诱导的离体工作大鼠心脏的机械和代谢紊乱。
Jpn J Pharmacol. 1995 Mar;67(3):233-41. doi: 10.1254/jjp.67.233.
引用本文的文献
1
PKM2 is a key regulator of cardiac lipid metabolism in mice.丙酮酸激酶M2是小鼠心脏脂质代谢的关键调节因子。
Mitochondrion. 2025 Jul 22;85:102070. doi: 10.1016/j.mito.2025.102070.
2
Phospholipids, the Masters in the Shadows during Healing after Acute Myocardial Infarction.磷脂：急性心肌梗死后愈合过程中的幕后大师。
Int J Mol Sci. 2023 May 6;24(9):8360. doi: 10.3390/ijms24098360.
3
Coenzyme-A-Independent Transacylation System; Possible Involvement of Phospholipase A2 in Transacylation.辅酶A非依赖性转酰基化系统；磷脂酶A2在转酰基化中的可能作用。
Biology (Basel). 2017 Mar 30;6(2):23. doi: 10.3390/biology6020023.
4
Differential effects of lysophosphatidylcholine and ACh on muscarinic K(+),non-selective cation and Ca(2+) currents in guinea-pig atrial cells.溶血磷脂酰胆碱和乙酰胆碱对豚鼠心房细胞毒蕈碱型钾离子、非选择性阳离子和钙离子电流的不同作用。
Fukushima J Med Sci. 2016 Jun 8;62(1):27-35. doi: 10.5387/fms.2015-23. Epub 2016 Feb 25.
5
Phospholipid alterations in the brain and heart in a rat model of asphyxia-induced cardiac arrest and cardiopulmonary bypass resuscitation.窒息诱导心脏骤停和体外循环复苏大鼠模型中脑和心脏的磷脂变化
Mol Cell Biochem. 2015 Oct;408(1-2):273-81. doi: 10.1007/s11010-015-2505-0. Epub 2015 Jul 10.
6
Examination of physiological function and biochemical disorders in a rat model of prolonged asphyxia-induced cardiac arrest followed by cardio pulmonary bypass resuscitation.长时间窒息诱导心脏骤停并进行体外循环复苏大鼠模型的生理功能及生化紊乱检测
PLoS One. 2014 Nov 10;9(11):e112012. doi: 10.1371/journal.pone.0112012. eCollection 2014.
7
Cell membrane-derived lysophosphatidylcholine activates cardiac ryanodine receptor channels.
Pflugers Arch. 2007 Jan;453(4):455-62. doi: 10.1007/s00424-006-0141-y. Epub 2006 Oct 7.
8
Potential mechanisms for the enhancement of HERG K+ channel function by phospholipid metabolites.磷脂代谢产物增强HERG钾通道功能的潜在机制。
Br J Pharmacol. 2004 Feb;141(4):586-99. doi: 10.1038/sj.bjp.0705646. Epub 2004 Jan 26.
9
Antigen-induced generation of lyso-phospholipids in human airways.抗原诱导的人类气道中溶血磷脂的生成。
J Exp Med. 1996 May 1;183(5):2235-45. doi: 10.1084/jem.183.5.2235.
10
The association of lysophosphatidylcholine with isolated cardiac myocytes.溶血磷脂酰胆碱与分离的心肌细胞的关联。
Lipids. 1990 Aug;25(8):450-4. doi: 10.1007/BF02538087.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
2
Phosphorus assay in column chromatography.柱色谱法中的磷测定
J Biol Chem. 1959 Mar;234(3):466-8.
3
Lipid-membrane interactions and the pathogenesis of ischemic damage in the myocardium.脂质-膜相互作用与心肌缺血损伤的发病机制。
Circ Res. 1981 Jan;48(1):1-16. doi: 10.1161/01.res.48.1.1.
4
Time course of changes in porcine myocardial phospholipid levels during ischemia. A reassessment of the lysolipid hypothesis.缺血期间猪心肌磷脂水平变化的时间进程。溶血磷脂假说的重新评估。
Circ Res. 1981 Aug;49(2):316-25. doi: 10.1161/01.res.49.2.316.
5
The effects of lysophosphatidylcholine, a toxic metabolite of ischemia, on the components of cardiac excitability in sheep Purkinje fibers.溶血磷脂酰胆碱（一种缺血性毒性代谢产物）对绵羊浦肯野纤维心脏兴奋性成分的影响。
Circ Res. 1981 Jul;49(1):16-30. doi: 10.1161/01.res.49.1.16.
6
Pathophysiological concentrations of lysophosphatides and the slow response.溶血磷脂的病理生理浓度与缓慢反应。
Am J Physiol. 1982 Aug;243(2):H187-95. doi: 10.1152/ajpheart.1982.243.2.H187.
7
Lysophosphatidylcholine causes cardiac arrhythmia.溶血磷脂酰胆碱会导致心律失常。
J Mol Cell Cardiol. 1982 Mar;14(3):173-5. doi: 10.1016/0022-2828(82)90115-8.
8
Incorporation of radiolabeled lysophosphatidyl choline into canine Purkinje fibers and ventricular muscle. Electrophysiological, biochemical, and autoradiographic correlations.放射性标记的溶血磷脂酰胆碱掺入犬浦肯野纤维和心室肌。电生理、生化及放射自显影相关性研究。
Circ Res. 1982 Jul;51(1):27-36. doi: 10.1161/01.res.51.1.27.
9
Phosphatidylcholine formation from exogenous lysophosphatidylcholine in isolated hamster heart.在离体仓鼠心脏中由外源性溶血磷脂酰胆碱生成磷脂酰胆碱
Biochim Biophys Acta. 1982 Apr 15;711(1):40-8. doi: 10.1016/0005-2760(82)90007-8.
10
Alterations in lysophosphatidylcholine levels of canine heart: modes of extraction and storage.犬心脏溶血磷脂酰胆碱水平的变化：提取和储存方式
Anal Biochem. 1984 Mar;137(2):277-81. doi: 10.1016/0003-2697(84)90085-x.
Zotero 插件