Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
PLoS One. 2021 Feb 16;16(2):e0246190. doi: 10.1371/journal.pone.0246190. eCollection 2021.
With the increase in the number of COVID-19 infections, the global health apparatus is facing insufficient resources. The main objective of the current study is to provide additional data regarding the clinical characteristics of the patients diagnosed with COVID-19, and in particular to analyze the factors associated with disease severity, lack of improvement, and mortality.
102 studies were included in the present meta-analysis, all of which were published before September 24, 2020. The studies were found by searching a number of databases, including Scopus, MEDLINE, Web of Science, and Embase. We performed a thorough search from early February until September 24. The selected papers were evaluated and analyzed using Stata software application version 14.
Ultimately, 102 papers were selected for this meta- analysis, covering 121,437 infected patients. The mean age of the patients was 58.42 years. The results indicate a prevalence of 79.26% for fever (95% CI: 74.98-83.26; I2 = 97.35%), 60.70% for cough (95% CI: 56.91-64.43; I2 = 94.98%), 33.21% for fatigue or myalgia (95% CI: 28.86-37.70; I2 = 96.12%), 31.30% for dyspnea (95% CI: 26.14-36.69; I2 = 97.67%), and 10.65% for diarrhea (95% CI: 8.26-13.27; I2 = 94.20%). The prevalence for the most common comorbidities was 28.30% for hypertension (95% CI: 23.66-33.18; I2 = 99.58%), 14.29% for diabetes (95% CI: 11.88-16.87; I2 = 99.10%), 12.30% for cardiovascular diseases (95% CI: 9.59-15.27; I2 = 99.33%), and 5.19% for chronic kidney disease (95% CI: 3.95-6.58; I2 = 96.42%).
We evaluated the prevalence of some of the most important comorbidities in COVID-19 patients, indicating that some underlying disorders, including hypertension, diabetes, cardiovascular diseases, and chronic kidney disease, can be considered as risk factors for patients with COVID-19 infection. Furthermore, the results show that an elderly male with underlying diseases is more likely to have severe COVID-19.
随着 COVID-19 感染人数的增加，全球卫生机构面临着资源不足的问题。本研究的主要目的是提供更多关于 COVID-19 患者临床特征的相关数据，特别是分析与疾病严重程度、改善不良和死亡率相关的因素。
本次荟萃分析共纳入了 102 项研究，所有研究均在 2020 年 9 月 24 日前发表。研究通过检索包括 Scopus、MEDLINE、Web of Science 和 Embase 在内的多个数据库来进行。我们从 2 月初开始进行全面检索，直到 9 月 24 日。使用 Stata 软件应用程序版本 14 对选定的论文进行评估和分析。
最终，本次荟萃分析共纳入了 102 篇论文，涵盖了 121437 名感染患者。患者的平均年龄为 58.42 岁。结果显示，发热的患病率为 79.26%（95%CI：74.98-83.26；I2 = 97.35%），咳嗽的患病率为 60.70%（95%CI：56.91-64.43；I2 = 94.98%），疲劳或肌痛的患病率为 33.21%（95%CI：28.86-37.70；I2 = 96.12%），呼吸困难的患病率为 31.30%（95%CI：26.14-36.69；I2 = 97.67%），腹泻的患病率为 10.65%（95%CI：8.26-13.27；I2 = 94.20%）。最常见合并症的患病率为高血压 28.30%（95%CI：23.66-33.18；I2 = 99.58%），糖尿病 14.29%（95%CI：11.88-16.87；I2 = 99.10%），心血管疾病 12.30%（95%CI：9.59-15.27；I2 = 99.33%）和慢性肾脏病 5.19%（95%CI：3.95-6.58；I2 = 96.42%）。
我们评估了 COVID-19 患者中一些最重要合并症的患病率，表明一些潜在疾病，包括高血压、糖尿病、心血管疾病和慢性肾脏病，可以被视为 COVID-19 感染患者的危险因素。此外，结果表明，患有潜在疾病的老年男性更有可能患有严重的 COVID-19。
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