Student research committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, 198571743, Tehran, IR Iran.
Faculty of Medicine, Zanjan University of Medical Sciences, 83153-45139, Zanjan, IR Iran.
Rev Cardiovasc Med. 2020 Sep 30;21(3):433-442. doi: 10.31083/j.rcm.2020.03.129.
The coronavirus disease 2019 (COVID-19) is a novel coronavirus infection that has rapidly spread worldwide, causing a pandemic. The main objective of this meta-analysis was to evaluate the prevalence of the most common symptoms and complications of COVID-19. All relevant studies on the clinical complications of COVID-19 have been identified by searching two web databases (i.e., PubMed and Scopus). Afterward, the relevant data were extracted from the selected studies, and then analyzed by the STATA (Version 14) random-effects model. The 30 studies selected for our meta-analysis covered 6,389 infected patients. The prevalence rates of the most common symptoms were as follows: fever: 84.30% (95% CI: 77.13-90.37; I2 = 97.74%), cough: 63.01% (95% CI: 57.63-68.23; I2 = 93.73%), dyspnea: 37.16% (95% CI: 27.31-47.57%; I2 = 98.32%), fatigue: 34.22% (95% CI: 26.29-42.62; I2 = 97.29%), and diarrhea: 11.47% (95% CI: 6.96-16.87; I2 = 95.58%). Moreover, the most prevalent complications were found to be acute respiratory distress syndrome (ARDS) with 33.15% (95% CI: 23.35-43.73; I2 = 98.56%), arrhythmia with 16.64% (95% CI: 9.34-25.5; I2 = 92.29%), acute cardiac injury with 15.68% (95% CI: 11.1-20.97; I2 = 92.45%), heart failure with 11.50% (95% CI: 3.45-22.83; I2 = 89.48%), and acute kidney injury (AKI) with 9.87% (95% CI: 6.18-14.25; I2 = 95.64%). In this study, we assessed the prevalence of the main clinical complications of COVID-19, and found that following respiratory complications, cardiac and renal complications are the most common clinical complications of COVID-19.
新型冠状病毒病（COVID-19）是一种新型冠状病毒感染，已迅速在全球范围内传播，造成大流行。本荟萃分析的主要目的是评估 COVID-19 的最常见症状和并发症的流行率。通过搜索两个网络数据库（即 PubMed 和 Scopus），确定了所有关于 COVID-19 临床并发症的相关研究。从选定的研究中提取相关数据，然后使用 STATA（版本 14）随机效应模型进行分析。我们的荟萃分析共纳入 30 项研究，涵盖了 6389 例感染患者。最常见症状的患病率如下：发热：84.30%（95%CI：77.13-90.37；I2 = 97.74%），咳嗽：63.01%（95%CI：57.63-68.23；I2 = 93.73%），呼吸困难：37.16%（95%CI：27.31-47.57%；I2 = 98.32%），疲劳：34.22%（95%CI：26.29-42.62%；I2 = 97.29%），腹泻：11.47%（95%CI：6.96-16.87%；I2 = 95.58%）。此外，最常见的并发症为急性呼吸窘迫综合征（ARDS），占 33.15%（95%CI：23.35-43.73%；I2 = 98.56%），心律失常占 16.64%（95%CI：9.34-25.5%；I2 = 92.29%），急性心脏损伤占 15.68%（95%CI：11.1-20.97%；I2 = 92.45%），心力衰竭占 11.50%（95%CI：3.45-22.83%；I2 = 89.48%），急性肾损伤（AKI）占 9.87%（95%CI：6.18-14.25%；I2 = 95.64%）。在本研究中，我们评估了 COVID-19 的主要临床并发症的流行率，发现除呼吸并发症外，心脏和肾脏并发症是 COVID-19 最常见的临床并发症。
