Department of Neurosciences and Mental Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy.
Department of Mental Health, San Paolo Hospital, ASST Santi Paolo e Carlo, Milan, Italy.
Psychiatry Res. 2021 Apr;298:113802. doi: 10.1016/j.psychres.2021.113802. Epub 2021 Feb 10.
The ongoing Corona Virus Disease 2019 (COVID-19) pandemic appears to increase risk for mental illness, either directly due to inflammation caused by the virus or indirectly due to related psychosocial stress, resulting in the development of both anxious-depressive and psychotic symptoms. The purpose of the present study was to assess the frequency and characteristics of all patients with First Episodes Psychosis (FEP) without COVID-19 infection hospitalized in the first four months since lockdown in Milan. We recruited sixty-two patients hospitalized between March 8 to July 8, 2020 versus those first hospitalized in the same period in 2019. The two subgroups were compared for sociodemographic variables and clinical characteristics of the episodes. Patients with FEP in 2020 were significantly older than patients with FEP in 2021, and presented with significantly less substances abuse. Interestingly, patients presenting with FEP in 2020 were significantly older than patients with FEP in 2019. These data are compatible with the greater vulnerability to stressful factors during the pandemic, as well as with the greater concern regarding a possible COVID-19 infection producing brain damage causing the FEP.
目前的 2019 年冠状病毒病（COVID-19）大流行似乎增加了患精神疾病的风险，这可能是由于病毒引起的炎症直接导致，也可能是由于相关的心理社会压力间接导致，从而导致焦虑抑郁和精神病症状的发展。本研究的目的是评估自米兰封锁以来的头四个月内所有未感染 COVID-19 的首发精神病（FEP）住院患者的频率和特征。我们招募了 62 名于 2020 年 3 月 8 日至 7 月 8 日住院的患者，与 2019 年同期首次住院的患者进行比较。比较了两组患者的社会人口统计学变量和发作的临床特征。与 2019 年的患者相比，2020 年的首发精神病患者年龄明显更大，且物质滥用的情况明显较少。有趣的是，2020 年首发精神病患者的年龄明显大于 2019 年的首发精神病患者。这些数据与大流行期间对压力因素的更大易感性以及对 COVID-19 感染可能导致大脑损伤导致首发精神病的更大关注相吻合。
