Meyer R A, Campbell J N
Department of Neurosurgery, School of Medicine, Johns Hopkins University, Baltimore, MD 21205.
Brain Res. 1988 Feb 16;441(1-2):81-6. doi: 10.1016/0006-8993(88)91385-6.
Conventional electrophysiological techniques for locating a cutaneous nociceptive receptor involve squeezing of the skin in the distribution of the nerve. A novel technique for locating nociceptive and chemospecific receptors has been developed, based on the coupling of action potential activity that occurs between two unmyelinated fibers in the peripheral nerve. Application of a punctate cold probe to the skin increases the latency of the coupled action potential when it is placed on the receptive field of the cutaneous receptor. More than half of the receptors which were located using this technique did not respond to mechanical or heat stimuli and therefore would not have been found using the standard search technique. Preliminary evidence suggests that some of these non-mechano-heat-sensitive receptors may be chemospecific receptors.
用于定位皮肤伤害性感受器的传统电生理技术包括挤压神经分布区域的皮肤。基于外周神经中两条无髓鞘纤维之间发生的动作电位活动耦合，已开发出一种用于定位伤害性感受器和化学特异性感受器的新技术。当将点状冷探针施加于皮肤并放置在皮肤感受器的感受野上时，会增加耦合动作电位的潜伏期。使用该技术定位的感受器中，超过一半对机械或热刺激无反应，因此使用标准搜索技术无法发现这些感受器。初步证据表明，其中一些非机械热敏感感受器可能是化学特异性感受器。
