Häbler H J, Jänig W, Koltzenburg M
Institut für Physiologie, Christian-Albrechts-Universität, Kiel, FRG.
Agents Actions. 1988 Dec;25(3-4):219-21. doi: 10.1007/BF01965016.
Single primary afferents supplying the cat urinary bladder were electrophysiologically recorded in the sacral dorsal roots. Under normal conditions, afferents were not spontaneously active when the bladder was empty and innocuous increases of intravesical pressure excited mainly thin myelinated, low-threshold mechanoreceptors. Less than 2.5% of all unmyelinated visceral afferents responded to a mechanical stimulus, but all had high, presumably noxious thresholds. During an acute inflammation induced with intravesical injections of 2.5% mustard oil or 50-100% turpentine oil both populations developed resting activity and changed their mechanosensitive properties. Out of the many unmyelinated afferents without appreciable mechanosensitivity, an entirely new subpopulation was activated by chemical irritants during an acute inflammation. Subsequently, some of these chemosensitive receptors started to display new mechanosensitive properties. This novel population of sensory neurones may contribute considerably to the pathogenesis of visceral pain states including reflex disturbances of bladder motility.
在猫的骶背根中对支配膀胱的单一初级传入神经进行了电生理记录。在正常情况下，当膀胱空虚时传入神经无自发活动，膀胱内压的无害性升高主要兴奋细有髓鞘的低阈值机械感受器。所有无髓鞘内脏传入神经中不到2.5%对机械刺激有反应，但它们都有较高的、可能是有害的阈值。在用膀胱内注射2.5%芥子油或50 - 100%松节油诱导的急性炎症期间，这两类传入神经都出现了静息活动并改变了它们的机械敏感特性。在许多没有明显机械敏感性的无髓鞘传入神经中，在急性炎症期间有一个全新的亚群被化学刺激物激活。随后，这些化学敏感感受器中的一些开始表现出新的机械敏感特性。这群新的感觉神经元可能在包括膀胱运动反射紊乱在内的内脏疼痛状态的发病机制中起重要作用。
