Department of Hemodialysis room.
Department of Surgical Oncology, The First People's Hospital of Fuyang Hangzhou, Hangzhou City, Zhejiang, China.
Medicine (Baltimore). 2021 Feb 5;100(5):e24275. doi: 10.1097/MD.0000000000024275.
To investigate serum level of high mobility group box protein-1 (HMGB1) and prognosis of patients with end-stage renal disease (ESRD) on hemodialysis (HD) and peritoneal dialysis (PD).This prospective cohort observational study included a total of 253 ESRD patients who came to our hospital for HD or PD from February 2013 to February 2015. Enzyme linked immunosorbent assay (ELISA) method was used to detect the serum level of HMGB1, interleukin (IL-6), IL-8, and tumor necrosis factor-alpha (TNF-α). The kidney disease quality of life short form (KDQOL-SF) and kidney disease targeted area (KDTA) was applied for evaluating the quality of life. Kaplan-Meier (K-M) curve was performed for survival time.Serum level of HMGB1 in patients on HD was higher than PD. HMGB1 levels were gradually decreased with the treatment of HD or PD. Furthermore, HMGB1 was positively correlated with IL-6 and TNF-α. Moreover, patients with higher HMGB1 had more complications than patients with lower HMGB1, but there was no difference for the survival rate. In addition, the quality of life was associated with different dialysis methods.The serum level of HMGB1 and prognosis of ESRD patients was associated with different dialysis methods.
探讨血液透析（HD）和腹膜透析（PD）的终末期肾病（ESRD）患者血清高迁移率族蛋白-1（HMGB1）水平及其预后。方法：本前瞻性队列观察性研究共纳入 2013 年 2 月至 2015 年 2 月期间因 HD 或 PD 来我院就诊的 253 例 ESRD 患者。采用酶联免疫吸附试验（ELISA）法检测血清 HMGB1、白细胞介素（IL）-6、IL-8 和肿瘤坏死因子-α（TNF-α）水平。采用肾脏病生活质量简表（KDQOL-SF）和肾脏病目标区域（KDTA）评估生活质量。采用 Kaplan-Meier（K-M）曲线进行生存时间分析。结果：HD 患者的血清 HMGB1 水平高于 PD 患者。随着 HD 或 PD 的治疗，HMGB1 水平逐渐降低。此外，HMGB1 与 IL-6 和 TNF-α呈正相关。此外，HMGB1 水平较高的患者比 HMGB1 水平较低的患者并发症更多，但生存率无差异。另外，生活质量与不同的透析方法有关。结论：HMGB1 血清水平与 ESRD 患者的预后与透析方法有关。
