Department of Otolaryngology - Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, U.S.A.
Department of Otolaryngology, Head and Neck Surgery, University of Adelaide, Adelaide, SA, Australia.
Laryngoscope. 2021 Mar;131(3):529-534. doi: 10.1002/lary.28822. Epub 2020 Jul 3.
The rate of positive margins in head and neck cancers has remained stagnant over the past three decades and is consistently associated with poor overall survival. This suggests that significant improvements must be made intraoperatively to ensure negative margins. We discuss the important role of fluorescence imaging to guide surgical oncology in head and neck cancer. This review includes a general overview of the principles of fluorescence, available fluorophores used for fluorescence imaging, and specific clinical applications of fluorescence-guided surgery, as well as challenges and future directions in head and neck surgical oncology. Laryngoscope, 131:529-534, 2021.
过去三十年来，头颈部癌症的阳性切缘率一直停滞不前，且始终与整体生存率差相关。这表明，必须在手术中进行重大改进，以确保切缘阴性。我们讨论了荧光成像在头颈部癌症外科手术中的重要作用。本文综述了荧光的基本原理、用于荧光成像的荧光团、荧光引导手术的具体临床应用以及头颈部肿瘤外科的挑战和未来方向。《喉镜》，131:529-534，2021。
