Magnan J, Lemay J, Tiberi M
Département de Pharmacologie, Faculté de Médecine, Université de Montréal, Qué, Canada.
Brain Res. 1988 Feb 1;466(2):300-3. doi: 10.1016/0165-3806(88)90057-0.
The existence of specific, high-affinity opioid binding sites was demonstrated in 21-week-old human fetuses with the use of tritiated etorphine, a non-selective opioid ligand. Binding capacities measured in the brain, the cerebellum and the spinal cord give values of 2.83, 3.71 and 5.42 pmol/g of tissue. Kd values do not vary from one region to the other and are respectively 0.29, 0.35 and 0.33 nM. These results are compared with the characteristics of opioid binding sites found in adults.
利用非选择性阿片样物质配体氚化埃托啡，在21周龄的人类胎儿中证实了特异性、高亲和力阿片样物质结合位点的存在。在大脑、小脑和脊髓中测得的结合能力分别为2.83、3.71和5.42 pmol/g组织。Kd值在不同区域之间没有差异，分别为0.29、0.35和0.33 nM。将这些结果与在成年人中发现的阿片样物质结合位点的特征进行了比较。
