耐受和非耐受大鼠中枢神经系统中3H-埃托啡的水平。
3H-etorphine levels in CNS of tolerant and non-tolerant rats.
作者信息
Luini A, Manara L
出版信息
Res Commun Chem Pathol Pharmacol. 1977 May;17(1):183-6.
PMID:560034
Abstract
Rats were rendered tolerant to etorphine by administering it daily for 5 days at doses of either 10 microgram/kg i.v. or 5 microgram/kg s.c..3H-etorphine was then injected to tolerant and non-tolerant rats; after 15 min their brain and spinal cord were removed for 3H-etorphine assay. Tolerant rats had lower 3H-etorphine levels in both tissues than control rats.
摘要
通过以10微克/千克静脉注射或5微克/千克皮下注射的剂量，每日给药5天，使大鼠对埃托啡产生耐受性。然后给耐受和未耐受的大鼠注射³H-埃托啡；15分钟后，取出它们的脑和脊髓进行³H-埃托啡测定。耐受大鼠的这两种组织中的³H-埃托啡水平均低于对照大鼠。
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