Department of Surgery, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Hoguk-ro 807, Buk-gu, Daegu, 41404, Republic of Korea.
Department of Surgery, Boonhongbitzro Hospital, Daegu, Republic of Korea.
BMC Cancer. 2021 Feb 16;21(1):166. doi: 10.1186/s12885-021-07881-x.
Although fat necrosis is a minor postoperative complication after breast reconstruction, occasionally it mimics to tumor recurrence in patients with breast cancer. Therefore, the surgeon should distinguish between benign fat necrosis and true local recurrence. The authors evaluated the clinical characteristics of fat necrosis after breast reconstruction and investigated the natural course of fat necrosis.
Between 2007 and 2013, a total of 362 patients underwent breast reconstruction after partial or total mastectomy for breast cancer in Kyungpook National University Hospital. Clinicopathologic characteristics and the occurrence of fat necrosis were assessed during surveillance for 10 years of mean follow-up period.
There were 42 cases (11.6%) of fat necrosis after breast reconstruction with partial or total mastectomy which were confirmed by needle or excision biopsy. The fat necrosis was resolved after a mean period of 45.9 months (SD, ± 42.1) and 26 cases (61.9%) of fat necrosis were almost completely resolved (less than 5 mm) during 10-year follow-up period.
Based on the natural course of fat necrosis, the fat necrosis after breast reconstruction can be only monitored, if pathologic confirmation was done. More than half of the cases will be resolved within 2-3 years.
尽管脂肪坏死是乳房重建术后的一种轻微并发症，但在乳腺癌患者中，它偶尔会模拟肿瘤复发。因此，外科医生应区分良性脂肪坏死和真正的局部复发。作者评估了乳房重建后脂肪坏死的临床特征，并研究了脂肪坏死的自然病程。
在 2007 年至 2013 年间，共有 362 例患者在庆北国立大学医院因乳腺癌接受了部分或全乳房切除术的乳房重建。在平均随访 10 年的时间里，评估了临床病理特征和脂肪坏死的发生情况。
在接受部分或全乳房切除术的乳房重建后，有 42 例（11.6%）发生脂肪坏死，经针吸或切除活检证实。脂肪坏死在平均 45.9 个月（SD，±42.1）后得到解决，在 10 年的随访期间，26 例（61.9%）脂肪坏死几乎完全解决（小于 5mm）。
根据脂肪坏死的自然病程，如果进行了病理证实，乳房重建后的脂肪坏死只能进行监测。超过一半的病例将在 2-3 年内得到解决。
