Tong Zhoujie, Peng Jie, Lan Hongtao, Sai Wenwen, Li Yulin, Xie Jiaying, Tan Yanmin, Zhang Wei, Zhong Ming, Wang Zhihao
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Department of Geriatric Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University; Shandong Key Laboratory of Cardiovascular Proteomics, Jinan, 250012, Shandong, China.
J Transl Med. 2021 Feb 16;19(1):72. doi: 10.1186/s12967-021-02739-z.
The prevalence of metabolic syndrome (Mets) is closely related to an increased incidence of cardiovascular events. Angiopoietin-like protein 4 (ANGPTL4) is contributory to the regulation of lipid metabolism, herein, may provide a target for gene-aimed therapy of Mets. This observational case control study was designed to elucidate the relationship between ANGPTL4 gene single nucleotide polymorphism (SNP) rs1044250 and the onset of Mets, and to explore the interaction between SNP rs1044250 and weight management on Mets.
We have recruited 1018 Mets cases and 1029 controls in this study. The SNP rs1044250 was genotyped with blood samples, base-line information and Mets-related indicators were collected. A 5-year follow-up survey was carried out to track the lifestyle interventions and changes in Mets-related indicators.
ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference (OR 1.618, 95% CI [1.119-2.340]; p = 0.011), elevated blood pressure (OR 1.323, 95% CI [1.002-1.747]; p = 0.048), and Mets (OR 1.875, 95% CI [1.363-2.580]; p < 0.001). The follow-up survey shows that rs1044250 CC genotype patients with weight gain have an increased number of Mets components (M [Q1, Q3]: CC 1 (0, 1), CT + TT 0 [- 1, 1]; p = 0.021); The interaction between SNP rs1044250 and weight management is a risk factor for increased systolic blood pressure (β = 0.075, p < 0.001) and increased diastolic blood pressure (β = 0.097, p < 0.001), the synergistic effect of weight management and SNP rs1044250 is negative (S < 1).
ANGPTL4 gene SNP rs1044250 is an independent risk factor for increased waist circumference and elevated blood pressure, therefore, for Mets. However, patients with wild type SNP 1044250 are more likely to have Mets when the body weight is increased, mainly due to elevated blood pressure.
代谢综合征（Mets）的患病率与心血管事件发生率的增加密切相关。血管生成素样蛋白4（ANGPTL4）有助于调节脂质代谢，在此，可能为Mets的基因靶向治疗提供靶点。本观察性病例对照研究旨在阐明ANGPTL4基因单核苷酸多态性（SNP）rs1044250与Mets发病之间的关系，并探讨SNP rs1044250与体重管理对Mets的相互作用。
本研究招募了1018例Mets患者和1029名对照。采用血样对SNP rs1044250进行基因分型，收集基线信息和与Mets相关的指标。进行了为期5年的随访调查，以跟踪生活方式干预措施以及与Mets相关指标的变化。
ANGPTL4基因SNP rs1044250是腰围增加（比值比1.618，95%置信区间[1.119 - 2.340]；p = 0.011）、血压升高（比值比1.323，95%置信区间[1.002 - 1.747]；p = 0.048）和Mets（比值比1.875，95%置信区间[1.363 - 2.580]；p < 0.001）的独立危险因素。随访调查显示，rs1044250 CC基因型体重增加的患者Mets组分数量增加（中位数[四分位数间距]：CC为1[0，1]，CT + TT为0[-1，1]；p = 0.021）；SNP rs1044250与体重管理之间的相互作用是收缩压升高（β = 0.075，p < 0.001）和舒张压升高（β = 0.097，p < 0.001）的危险因素，体重管理与SNP rs1044250的协同作用为负（S < 1）。
ANGPTL4基因SNP rs1044250是腰围增加和血压升高的独立危险因素，因此也是Mets的独立危险因素。然而，野生型SNP 1044250的患者体重增加时更易发生Mets，主要原因是血压升高。
