Tong Zhoujie, Qi Jia, Ma Weixuan, Wang Di, Hu Boang, Li Yulin, Jia Xu, Peng Jie, Wang Zhihao, Zhong Ming
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Cardiology, Zibo Central Hospital, Zibo, China.
Front Genet. 2021 Dec 10;12:786393. doi: 10.3389/fgene.2021.786393. eCollection 2021.
Metabolic Syndrome (MetS) is widespread across the world. Gene targeted therapy and risk management are promising approaches for MetS intervention. gene rs237025 polymorphism is related to an increased risk of diabetes, therefore, it is considered a target for the gene polymorphism research of MetS. A case-control study was performed to study the interaction of rs237025 with MetS and the components of MetS. A 5-years follow-up survey was carried out to elucidate the crosstalk between rs237025 and weight management, and the synergistic effect on MetS. A total of 1,008 MetS patients and 1,047 controls were recruited in this research. By cross-section study, we find that rs237025 is an independent risk factor for increased Waist Circumference (WC), elevated Triglyceride (TG), elevated Fasting Plasma Glucose (FPG), and MetS. Cross-over analysis identifies the interaction of rs237025 and weight management as a risk factor for MetS, the synergistic effects of rs237025 and weight management are negative to WC, TG, and High-density Lipoprotein-cholesterol (HDL-c). gene rs237025 is related to increased risk of MetS, weight management is essential to MetS intervention, especially for patients with rs237025 polymorphism.
代谢综合征（MetS）在全球广泛存在。基因靶向治疗和风险管理是代谢综合征干预的有前景的方法。基因rs237025多态性与糖尿病风险增加有关，因此，它被认为是代谢综合征基因多态性研究的一个靶点。进行了一项病例对照研究，以研究rs237025与代谢综合征及其组成成分之间的相互作用。开展了一项为期5年的随访调查，以阐明rs237025与体重管理之间的相互影响，以及对代谢综合征的协同作用。本研究共招募了1008例代谢综合征患者和1047名对照。通过横断面研究，我们发现rs237025是腰围（WC）增加、甘油三酯（TG）升高、空腹血糖（FPG）升高和代谢综合征的独立危险因素。交叉分析确定rs237025与体重管理的相互作用是代谢综合征的一个危险因素，rs237025与体重管理的协同作用对腰围、甘油三酯和高密度脂蛋白胆固醇（HDL-c）有负面影响。基因rs237025与代谢综合征风险增加有关，体重管理对代谢综合征干预至关重要，尤其是对于具有rs237025多态性的患者。
