非达霉素对具有高活性。

Fidaxomicin has high activity against .

机构信息

National Clinical Laboratory on Tuberculosis, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing Chest Hospital, Capital Medical University, Beijing, PR China.

College of Veterinary Medicine, China Agricultural University, Beijing, PR China.

出版信息

J Med Microbiol. 2021 Mar;70(3). doi: 10.1099/jmm.0.001324. Epub 2021 Feb 17.

DOI:10.1099/jmm.0.001324

PMID:33593474

Abstract

This study aimed to evaluate whether the antibiotic fidaxomicin has activity against (Mtb). 38 fully drug-sensitive Mtb strains and 34 multidrug-resistant tuberculosis (MDR-TB) strains were tested using the microplate alamar blue assay (MABA) method to determine the minimum inhibitory concentrations (MICs) for fidaxomicin and rifampicin. Fidaxomicin has high activity against Mtb and is a potential drug to treat Mtb, and MDR-TB infections in particular.

摘要

本研究旨在评估抗生素菲达霉素对（结核分枝杆菌）是否具有活性。采用微量肉汤稀释法（MABA）检测 38 株完全药敏结核分枝杆菌株和 34 株耐多药结核分枝杆菌（MDR-TB）株的最小抑菌浓度（MIC），以评估菲达霉素和利福平的 MIC 值。菲达霉素对结核分枝杆菌具有高度活性，是治疗结核分枝杆菌和耐多药结核分枝杆菌感染的潜在药物。