姐妹染色单体的空间组织。
The Spatial Organization of Sister Chromatids.
机构信息
Advanced Microscopy Facility, VBCF, Vienna Biocenter (VBC), Dr. Bohr-Gasse 9, 1030 Vienna, Austria; Department of Chromosome Biology, Max Perutz Labs, University of Vienna, Vienna Biocenter (VBC), Dr. Bohr-Gasse 9, 1030 Vienna, Austria.
出版信息
Trends Biochem Sci. 2021 Apr;46(4):255-257. doi: 10.1016/j.tibs.2021.01.010. Epub 2021 Feb 13.
Understanding how genomes are spatially organized is central to many aspects of cell biology. However, it has been difficult to study the relationships between sister chromatids because sequencing-based techniques such as Hi-C could not distinguish identical sister DNAs. Here, I discuss recent developments that provide insights into sister chromatid organization.
了解基因组如何在空间上进行组织是细胞生物学的许多方面的核心。然而，由于基于测序的技术（如 Hi-C）无法区分相同的姐妹 DNA，因此研究姐妹染色单体之间的关系一直很困难。在这里，我将讨论最近的一些进展，这些进展为了解姐妹染色单体的组织提供了新的视角。
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