Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, and Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Dimension Inx, Chicago, IL, USA.
Trends Biotechnol. 2021 Aug;39(8):824-837. doi: 10.1016/j.tibtech.2021.01.008. Epub 2021 Feb 13.
Recent research in tissue engineering and regenerative medicine has elucidated the importance of the matrisome. The matrisome, effectively the skeleton of an organ, provides physical and biochemical cues that drive important processes such as differentiation, proliferation, migration, and cellular morphology. Leveraging the matrisome to control these and other tissue-specific processes will be key to developing transplantable bioprosthetics. In the ovary, the physical and biological properties of the matrisome have been implicated in controlling the important processes of follicle quiescence and folliculogenesis. This expanding body of knowledge is being applied in conjunction with new manufacturing processes to enable increasingly complex matrisome engineering, moving closer to emulating tissue structure, composition, and subsequent functions which can be applied to a variety of tissue engineering applications.
最近的组织工程和再生医学研究阐明了细胞外基质的重要性。细胞外基质实际上是器官的“骨架”，它提供了物理和生化线索，驱动着分化、增殖、迁移和细胞形态等重要过程。利用细胞外基质来控制这些过程和其他组织特异性过程将是开发可移植生物假体的关键。在卵巢中，细胞外基质的物理和生物学特性被认为与控制卵泡静止和卵泡发生的重要过程有关。这一不断扩大的知识体系正在与新的制造工艺相结合，以实现更复杂的细胞外基质工程，更接近模拟组织结构、组成和随后的功能，这些功能可以应用于各种组织工程应用。
