Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Dermatology Service, Hospital das Clínicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
An Bras Dermatol. 2021 Mar-Apr;96(2):228-230. doi: 10.1016/j.abd.2020.07.008. Epub 2021 Jan 31.
As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. With the finding of alcohol-resistant bacilli and Mycobacterium tuberculosis DNA in a cutaneous fragment, through polymerase chain reaction, the diagnosis of gummatous tuberculosis was confirmed, probably secondary to hematogenous dissemination from an intestinal focus.
随着传染病和寄生虫病治疗的改善，这些疾病的患病率有所下降。然而，随着免疫生物制剂的广泛应用，出现了机会性感染，尤其是在非典型表现的情况下。本研究报告了一例接受英夫利昔单抗治疗克罗恩病的患者，该患者出现腹泻、体重减轻、腹痛、发热和皮下红斑性结节，且呈自发性波动和溃疡。通过聚合酶链反应，在皮肤切片中发现抗酒精杆菌和结核分枝杆菌 DNA，诊断为树胶肿性结核，可能是肠道病灶血行播散所致。
