Department Pulmonary Diseases, Noordwest Ziekenhuisgroep, Alkmaar, Noord-Holland, The Netherlands.
Pulmonary Diseases, Vrije Universiteit Amsterdam, Amsterdam, Noord-Holland, The Netherlands.
BMJ Open Respir Res. 2021 Feb;8(1). doi: 10.1136/bmjresp-2020-000761.
We developed the chronic obstructive pulmonary disease (COPD)-Lower Respiratory Tract Infection-Visual Analogue Score (c-LRTI-VAS) in order to easily quantify symptoms during exacerbations in patients with COPD. This study aimed to validate this score.
In our study, patients with stable COPD as well as those with an acute exacerbations of COPD (AECOPD) were included. The results of c-LRTI-VAS were compared with other markers of disease activity (lung function parameters, oxygen saturation and two health related quality of life questionnaires (St Georges Respiratory Questionnaire (SGRQ) and Clinical COPD Questionnaire (CCQ)) and validity, reliability and responsiveness were assessed.
Eighty-eight patients with clinically stable COPD and 102 patients who had an AECOPD completed the c-LRTI-VAS questionnaire. When testing on two separate occasions for repeatability, no statistically significant difference between total scores was found 0.143 (SD 5.42) (p=0.826). Internal consistency was high across items (Cronbach's apha 0.755). Correlation with SGRQ and CCQ total scores was moderate to high. After treatment for hospitalised AECOPD, the mean c-LRTI-VAS total score improved 8.14 points (SD 9.13; p≤0.001).
c-LRTI-VAS showed proper validity, responsiveness to change and moderate to high correlation with other questionnaires. It, therefore, appears a reliable tool for symptom measurement during AECOPD.
NCT01232140.
我们开发了慢性阻塞性肺疾病（COPD）-下呼吸道感染-视觉模拟评分（c-LRTI-VAS），以便在 COPD 患者的加重期轻松量化症状。本研究旨在验证该评分。
本研究纳入了稳定期 COPD 患者和急性加重期 COPD（AECOPD）患者。将 c-LRTI-VAS 的结果与其他疾病活动标志物（肺功能参数、氧饱和度和两种健康相关生活质量问卷（圣乔治呼吸问卷（SGRQ）和临床 COPD 问卷（CCQ））进行比较，并评估了其有效性、可靠性和反应性。
88 例临床稳定期 COPD 患者和 102 例 AECOPD 患者完成了 c-LRTI-VAS 问卷。在两次单独测试的可重复性中，总分之间没有统计学上的显著差异 0.143（SD 5.42）（p=0.826）。各项目的内部一致性较高（Cronbach's apha 0.755）。与 SGRQ 和 CCQ 总分的相关性为中度至高度。AECOPD 住院治疗后，c-LRTI-VAS 总分平均改善 8.14 分（SD 9.13；p≤0.001）。
c-LRTI-VAS 表现出适当的有效性、对变化的反应性以及与其他问卷的中度至高度相关性。因此，它似乎是一种可靠的工具，可用于 AECOPD 期间的症状测量。
NCT01232140。
