哮喘和/或 COPD 患者的缺勤情况：一项基于人群的研究。
Work absence in patients with asthma and/or COPD: a population-based study.
机构信息
University of Groningen, University Medical Center Groningen, Groningen Institute for Asthma and COPD (GRIAC), Department of General Practice & Elderly Care Medicine, Groningen, The Netherlands.
General Practitioners Research Institute, Groningen, The Netherlands.
出版信息
NPJ Prim Care Respir Med. 2021 Feb 16;31(1):9. doi: 10.1038/s41533-021-00217-z.
Chronic obstructive pulmonary disease (COPD) and asthma impact on work productivity, but their population-based burden and clinical predictors are understudied. In this observational, real-life study, work absence of 14,383 asthma and/or COPD patients present in the MAJORICA cohort (Spain) was compared with the general population. Using multivariable regression, we studied the association of work absence with demographic and clinical characteristics. Patients with asthma and/or COPD had more work absence than the general population (15.2% vs 8.9%, p < 0.0001). Patients with asthma had more often periods of work absence compared to patients with COPD (16.0% vs 12.8%, p < 0.0001). The number of days absent were, however, less in asthma than in COPD (median: 15 days [IQR: 5-51] vs 39 days [IQR: 13-134], p < 0.001). Patients with asthma-COPD overlap were in between (14.5% with absence; median: 27 days [IQR: 10-82]). Comorbid anxiety, allergic rhinitis, and sleep apnoea were independently associated with more work absence.
慢性阻塞性肺疾病（COPD）和哮喘会影响工作效率，但它们在人群中的负担和临床预测因素尚未得到充分研究。在这项观察性、真实世界的研究中，比较了 MAJORICA 队列（西班牙）中 14383 例哮喘和/或 COPD 患者的缺勤情况与一般人群。我们使用多变量回归研究了与工作缺勤相关的人口统计学和临床特征。与一般人群相比，哮喘和/或 COPD 患者的缺勤率更高（15.2%比 8.9%，p<0.0001）。与 COPD 患者相比，哮喘患者更经常出现缺勤期（16.0%比 12.8%，p<0.0001）。然而，哮喘患者的缺勤天数较少（中位数：15 天[IQR：5-51]比 39 天[IQR：13-134]，p<0.001）。哮喘-COPD 重叠患者则处于两者之间（14.5%的患者缺勤；中位数：27 天[IQR：10-82]）。合并焦虑、过敏性鼻炎和睡眠呼吸暂停与更多的工作缺勤独立相关。
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