International Medical School, Management and Science University, 40100, Shah Alam, Selangor, Malaysia.
Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia Health Campus, 16150, Kubang Kerian, Kelantan, Malaysia.
Purinergic Signal. 2021 Jun;17(2):201-213. doi: 10.1007/s11302-021-09764-z. Epub 2021 Feb 17.
Pain is the most common symptom reported by patients with rheumatoid arthritis (RA) even after the resolution of chronic joint inflammation. It is believed that RA-associated pain is not solely due to inflammation, but could also be attributed to aberrant modifications to the central nervous system. The P2X4 receptor (P2X4R) is an ATP-activated purinergic receptor that plays a significant role in the transmission of information in the nervous system and pain. The involvement of P2X4R during the pathogenesis of chronic inflammatory pain and neuropathic pain is well-established. The attenuation of this receptor alleviates disease pathogenesis and related symptoms, including hyperalgesia and allodynia. Although some studies have revealed the contribution of P2X4R in promoting joint inflammation in RA, how it implicates pain associated with RA at peripheral and central nervous systems is still lacking. In this review, the possible contributions of P2X4R in the nervous system and how it implicates pain transmission and responses were examined.
疼痛是类风湿关节炎（RA）患者最常见的症状，即使在慢性关节炎症消退后也是如此。人们认为，与 RA 相关的疼痛不仅是由于炎症引起的，还可能是由于中枢神经系统的异常改变所致。P2X4 受体（P2X4R）是一种 ATP 激活的嘌呤能受体，在神经系统和疼痛信息传递中发挥重要作用。P2X4R 在慢性炎症性疼痛和神经性疼痛的发病机制中的作用已得到充分证实。该受体的衰减可减轻疾病的发病机制和相关症状，包括痛觉过敏和感觉异常。尽管一些研究已经揭示了 P2X4R 在促进 RA 关节炎症中的作用，但它如何影响 RA 外周和中枢神经系统相关疼痛仍不清楚。在这篇综述中，我们探讨了 P2X4R 在神经系统中的可能作用，以及它如何影响疼痛的传递和反应。
