Department of Gastroenterology and Hepatology/Inflammatory Bowel Disease Group, Hokkaido University Faculty of Medicine and Graduate School of Medicine, Hokkaido University Hospital, Sapporo, Japan.
Division of Laboratory and Transfusion Medicine/Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan.
J Ultrasound Med. 2021 Dec;40(12):2595-2605. doi: 10.1002/jum.15645. Epub 2021 Feb 17.
Transabdominal ultrasonography (US) has been reported as a useful tool for evaluating Crohn's disease (CD) activity. Endoscopic findings and Crohn's disease activity index (CDAI) are currently considered the gold standard for assessing CD activity. We assessed the correlation between US and double-balloon endoscopy (DBE), and CDAI for evaluating CD activity.
We analyzed patients with CD undergoing US and DBE within 10 days between the procedures. The intestine was divided into four segments and analyzed by the US scoring system (US-CD) and the simple endoscopic score for Crohn's disease (SES-CD). CDAI was compared with US-CD and SES-CD. Spearman's rank correlation coefficient was used for statistical analysis.
Twenty-five patients with CD (11 women, 14 men; mean age 35.4 ± 14.9 years, range 16-65 years) were enrolled. Twenty-four patients received antitumor necrosis factor inhibitor therapy. CDAI was 128.1 (range 36-227). A significant moderate correlation was found between the US-CD and SES-CD in all segments (ρ = .64, P < .01). The US-CD showed a strong correlation with CDAI (ρ = .78, P < .01), whereas the SES-CD showed a moderate correlation (ρ = .55, P < .05).
US-CD and SES-CD showed a moderate correlation for assessing CD activity. US-CD showed a stronger correlation with CDAI than SES-CD, suggesting that US could more accurately evaluate the disease activity.
经腹超声（US）已被报道为评估克罗恩病（CD）活动的有用工具。内镜检查结果和克罗恩病活动指数（CDAI）目前被认为是评估 CD 活动的金标准。我们评估了 US 与双气囊内镜（DBE）和 CDAI 用于评估 CD 活动的相关性。
我们分析了在两次检查之间 10 天内接受 US 和 DBE 的 CD 患者。肠道分为四个节段，通过 US 评分系统（US-CD）和简单的克罗恩病内镜评分（SES-CD）进行分析。比较 CDAI 与 US-CD 和 SES-CD。采用 Spearman 秩相关系数进行统计学分析。
共纳入 25 例 CD 患者（11 名女性，14 名男性；平均年龄 35.4±14.9 岁，范围 16-65 岁）。24 例患者接受了肿瘤坏死因子抑制剂治疗。CDAI 为 128.1（范围 36-227）。所有节段的 US-CD 与 SES-CD 均呈中度显著相关（ρ=0.64，P<0.01）。US-CD 与 CDAI 呈强相关（ρ=0.78，P<0.01），而 SES-CD 呈中度相关（ρ=0.55，P<0.05）。
US-CD 和 SES-CD 对评估 CD 活动具有中度相关性。US-CD 与 CDAI 的相关性强于 SES-CD，提示 US 能更准确地评估疾病活动度。
