血管紧张素 II 在慢性间歇性低氧诱导的高血压和认知功能下降中的作用。
Role of angiotensin II in chronic intermittent hypoxia-induced hypertension and cognitive decline.
机构信息
Breathing REsearch And THErapeutics (BREATHE) Center, University of Florida, Gainesville, Florida.
Department of Physical Therapy, University of Florida, Gainesville, Florida.
出版信息
Am J Physiol Regul Integr Comp Physiol. 2021 Apr 1;320(4):R519-R525. doi: 10.1152/ajpregu.00222.2020. Epub 2021 Feb 17.
Abstract
Sleep apnea is characterized by momentary interruptions in normal respiration and leads to periods of decreased oxygen, or intermittent hypoxia. Chronic intermittent hypoxia is a model of the hypoxemia associated with sleep apnea and results in a sustained hypertension that is maintained during normoxia. Adaptations of the carotid body and activation of the renin-angiotensin system may contribute to the development of hypertension associated with chronic intermittent hypoxia. The subsequent activation of the brain renin-angiotensin system may produce changes in sympathetic regulatory neural networks that support the maintenance of the hypertension associated with intermittent hypoxia. Hypertension and sleep apnea not only increase risk for cardiovascular disease but are also risk factors for cognitive decline and Alzheimer's disease. Activation of the angiotensin system could be a common mechanism that links these disorders.
摘要
睡眠呼吸暂停的特征是正常呼吸的短暂中断，导致氧气减少或间歇性缺氧。慢性间歇性缺氧是与睡眠呼吸暂停相关的低氧血症的模型，导致持续的高血压，在正常氧合期间维持。颈动脉体的适应和肾素-血管紧张素系统的激活可能有助于与慢性间歇性缺氧相关的高血压的发展。随后脑肾素-血管紧张素系统的激活可能导致支持间歇性缺氧相关高血压维持的交感神经调节神经网络的变化。高血压和睡眠呼吸暂停不仅增加了心血管疾病的风险，也是认知能力下降和阿尔茨海默病的危险因素。血管紧张素系统的激活可能是将这些疾病联系起来的共同机制。
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