Miyamura Keitaro, Nawa Nobutoshi, Isumi Aya, Doi Satomi, Ochi Manami, Fujiwara Takeo
Department of Global Health Promotion, Tokyo Medical and Dental University, Tokyo, Japan.
National Institute of Public Health, Department of Health and Welfare Services, Saitama, Japan.
J Clin Endocrinol Metab. 2021 Jun 16;106(7):e2738-e2748. doi: 10.1210/clinem/dgab094.
Passive smoking in childhood has been reported to be associated with dyslipidemia in Western countries. However, this association in Asian countries remains unclear. Further, no study has investigated the sex difference of the association.
This study aimed to elucidate the association between passive smoking and dyslipidemia in adolescent boys and girls in Japan.
We used a cross-sectional data of junior high school students in the Adachi Child Health Impact of Living Difficulty (A-CHILD) study in Adachi City, Tokyo, Japan in 2016 and 2018. Of the 1431 available students, 1166 students and their parents responded to the survey, including frequency of passive smoking (response rate 81.5%). We assessed dyslipidemia using total cholesterol (TC) levels, low-density lipoprotein cholesterol (LDL-C) levels and high-density lipoprotein cholesterol (HDL-C) levels. The association between passive smoking and dyslipidemia was evaluated by using multivariate regression analyses adjusted for socioeconomic status and lifestyle factors stratified by boys (N = 564) and girls (N = 602).
Among boys, HDL-C levels were significantly lower if exposed to passive smoking frequently, compared with those not exposed (β = -3.19; 95% CI, -5.84 to -0.55). However, this trend does not hold true among girls. Passive smoking was not associated with TC levels and LDL-C levels in either boys or girls.
We found that exposure to passive smoking was associated with HDL-C level among boys in Japan, but not in girls. Further longitudinal study is needed to confirm the association between passive smoking and dyslipidemia among boys in Japan.
在西方国家，据报道儿童被动吸烟与血脂异常有关。然而，亚洲国家的这种关联仍不明确。此外，尚无研究调查这种关联的性别差异。
本研究旨在阐明日本青少年男孩和女孩中被动吸烟与血脂异常之间的关联。
我们使用了2016年和2018年在日本东京足立市进行的足立儿童生活困难健康影响（A-CHILD）研究中的初中生横断面数据。在1431名可用学生中，1166名学生及其家长回复了调查问卷，包括被动吸烟频率（回复率81.5%）。我们使用总胆固醇（TC）水平、低密度脂蛋白胆固醇（LDL-C）水平和高密度脂蛋白胆固醇（HDL-C）水平评估血脂异常。通过对按男孩（N = 564）和女孩（N = 602）分层的社会经济状况和生活方式因素进行调整的多变量回归分析，评估被动吸烟与血脂异常之间的关联。
在男孩中，经常暴露于被动吸烟的人群与未暴露人群相比，HDL-C水平显著较低（β = -3.19；95%CI，-5.84至-0.55）。然而，这种趋势在女孩中并不成立。被动吸烟与男孩或女孩的TC水平和LDL-C水平均无关联。
我们发现，在日本，被动吸烟与男孩的HDL-C水平有关，但与女孩无关。需要进一步的纵向研究来证实日本男孩中被动吸烟与血脂异常之间的关联。
