Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China.
University of Chinese Academy of Sciences, 19A Yuquan Road, Beijing 100049, P. R. China.
Nano Lett. 2021 Mar 10;21(5):2088-2093. doi: 10.1021/acs.nanolett.0c04778. Epub 2021 Feb 17.
Immunogenic cell death (ICD), a manner of tumor cell death that can trigger antitumor immune responses, has received extensive attention as a potential synergistic modality for cancer immunotherapy. Although many calcium ion (Ca) nanomodulators have been developed for cancer therapy through mitochondrial Ca overload, their ICD-inducing properties have not been explored. Herein, an acid-sensitive PEG-decorated calcium carbonate (CaCO) nanoparticle incorporating curcumin (CUR; a Ca enhancer) (CaCUR) was prepared using a simple one-pot strategy. CaCUR served as not only a Ca nanomodulator inducing efficient mitochondrial Ca overload but also an ICD inducer during improved synergistic cancer therapy. Combination of CaCUR with ultrasound (US), CaCUR+US, led to an enhanced ICD effect attributable to the enhanced mitochondrial Ca overload, along with subsequent upregulation of reactive oxygen species levels. CaCUR also facilitates photoacoustic/fluorescence dual-mode imaging, as well as effectively suppressing tumor growth and metastasis, indicating promising theranostic properties.
免疫原性细胞死亡（ICD）是一种能够引发抗肿瘤免疫反应的肿瘤细胞死亡方式，作为癌症免疫治疗的一种潜在协同方式，受到了广泛关注。尽管已经开发出许多通过线粒体钙超载来治疗癌症的钙离子（Ca）纳米调节剂，但它们的 ICD 诱导特性尚未得到探索。在此，通过简单的一锅法制备了一种酸敏感的聚乙二醇（PEG）修饰的碳酸钙（CaCO）纳米粒子，其中包含姜黄素（CUR；一种 Ca 增强剂）（CaCUR）。CaCUR 不仅作为一种 Ca 纳米调节剂，诱导有效的线粒体 Ca 超载，而且在协同癌症治疗中作为 ICD 诱导剂。CaCUR 与超声（US）的联合应用（CaCUR+US）导致 ICD 效应增强，归因于增强的线粒体 Ca 超载，以及随后的活性氧水平上调。CaCUR 还促进了光声/荧光双模成像，并有效地抑制了肿瘤的生长和转移，表明其具有有前途的治疗诊断特性。
