Humboldt-Universität zu Berlin, Department of Chemistry, Laboratory for Organic Synthesis of Functional Systems, Brook-Taylor-Str. 2, Berlin D-12489, Germany.
Max Planck Institute of Colloids and Interfaces, Department of Biomaterials, Potsdam 14424, Germany.
Soft Matter. 2021 Mar 4;17(8):2028-2033. doi: 10.1039/d0sm02118k.
A His-rich domain of preCollagen-D found in byssal threads is derivatized with Cys and Dopa flanks to allow for mussel-inspired polymerization. Artificial mussel glue proteins are accessed that combine cysteinyldopa for adhesion with sequences for pH or Zn2+ induced β-sheet formation. The artificial constructs show strong adsorption to Al2O3, the resulting coatings tolerate hypersaline conditions and cohesion is improved by activating the β-sheet formation, that enhances E-modulus up to 60%.
在贻贝丝中发现富含 His 的前胶原-D 结构域，其 Cys 和 Dopa 侧翼被衍生化，以允许贻贝启发的聚合。可以获得人工贻贝胶蛋白，它们将半胱氨酸二酪氨酸用于粘附与 pH 或 Zn2+诱导的β-折叠形成序列相结合。人工构建体对 Al2O3 具有强烈的吸附作用，所得涂层耐受高盐条件，通过激活β-折叠形成提高内聚强度，将 E-模量提高至 60%。
