金丝桃素：生产与微生物学测定
Chartreusin: production and microbiological assay.
作者信息
Hanka L J, Gerpheide S A
出版信息
Antimicrob Agents Chemother. 1977 Nov;12(5):571-2. doi: 10.1128/AAC.12.5.571.
Abstract
Chartreusin was produced in the fermentation liquors of Streptomyces chartreusis at peak concentrations of 200 to 300 mug/ml. The titers could be increased by 200 to 300% or more by incorporating d-fucose, a part of the chartreusin molecule, into the fermentation media. A microbiological assay with Sarcina lutea could detect concentrations of the drug of 0.5 to 1.0 mug/ml.
摘要
酒霉素是由浅蓝链霉菌发酵液产生的，其峰值浓度为200至300微克/毫升。通过将酒霉素分子的一部分d-岩藻糖加入发酵培养基中，效价可提高200%至300%或更多。用藤黄八叠球菌进行的微生物测定可检测到0.5至1.0微克/毫升的药物浓度。
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