RISCOP-Cognitive profile in a Portuguese cohort of radiological isolated syndrome patients: A case-control study.
作者信息
Carvalho Vanessa, Soares Carolina, Gomes Inês, Carvalho Andreia, Serrazina Filipa, Rodrigues Sofia Grenho, Pinheiro Joaquim, Marques Inês Brás, Correia Filipe, Correia Ana Sofia, de Sá João, Sousa Lívia, Vale José, Sá Maria José, Sousa Cláudia, Ferreira João
机构信息
Department of Neurology, Hospital Pedro Hispano/Unidade Local de Saúde de Matosinhos, Matosinhos, Portugal.
Department of Neurology, Centro Hospitalar Universitário de São João, EPE, Porto, Portugal.
出版信息
Mult Scler Relat Disord. 2021 May;50:102832. doi: 10.1016/j.msard.2021.102832. Epub 2021 Feb 10.
INTRODUCTION
Radiologically isolated syndrome (RIS) refers to the incidental discovery of white matter lesions suggestive of MS, on brain MRI, in asymptomatic patients. Recent studies suggest similar features of cognitive impairment between RIS and MS patients. Also, lower levels of health-related quality of life (QOL) and fatigue are reported in such patients.
AIMS
characterize and compare the cognitive profile of a multicentric Portuguese cohort of RIS patients with a control group.
METHODS
multicentric comparative study of a cohort of adult patients with RIS, and age and gender-matched controls followed in the headache outpatient clinic with prior MRI not fulfilling criteria for RIS diagnosis. We conducted interviews with participants, collected clinical data and applied the BICAMS battery and self-reported questionnaires (HADS, MFIS, MSQOL-54).
RESULTS
we evaluated 31 patients with RIS (median age 46 years, IQR [(Dusankova et al., 2012-52], 72% women) and 19 control individuals (median age 32 years, IQR [(O'Jile et al., 2005-48], 71% women). Prevalence of cognitive impairment did not differ between groups (16% of the RIS and 10% of the controls, p=0.579). We found no differences between groups on the BICAMS tests, although the results of the California Verbal Learning Test (CVLT-II) score presented a trend to significance, with a lower value on the RIS group (53.9 vs. 59.3, p=0.066). There were no significant differences regarding fatigue, QOL, anxiety/depression scores.
CONCLUSION
this is the first study on a Portuguese cohort of RIS patients assessing cognitive profile with BICAMS. A non-neglectable part of our cohort presented cognitive impairment. Our findings add to previous studies in suggesting that a more pronounced impairment of verbal memory and learning, evaluated by CVLT-II, may be present in RIS patients compared to controls. BICAMS should be assessed on future studies with larger cohorts.
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