Sydow O
Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
Clin Chim Acta. 1988 Feb 29;172(1):57-63. doi: 10.1016/0009-8981(88)90120-9.
Previous studies have shown a selective reduction of the sialic acid concentration in erythrocyte membranes in patients with myotonic dystrophy. In order to locate this deficiency, chloroform/methanol/H2O extractions of erythrocyte membranes were analyzed in patients with myotonic dystrophy and in matched healthy reference individuals. In the patients, significant reductions of the sialic acid concentration were found in the aqueous phase (p = 0.03) containing mainly glycophorin A as well as in the band-3-containing interphase (p less than 0.005). These findings may be related to certain previously reported membrane abnormalities in myotonic dystrophy.
先前的研究表明，强直性肌营养不良患者红细胞膜中的唾液酸浓度会选择性降低。为了确定这种缺陷的位置，对强直性肌营养不良患者和匹配的健康对照个体的红细胞膜进行了氯仿/甲醇/H2O萃取分析。在患者中，主要含有血型糖蛋白A的水相中唾液酸浓度显著降低（p = 0.03），在含有带3蛋白的中间相中也显著降低（p < 0.005）。这些发现可能与先前报道的强直性肌营养不良患者某些膜异常有关。
