A new rare heritable fragile site at 8q24.1 found in a Japanese population.

A new rare fragile site, fra(8)(q24.1) (Takahashi et al. 1987), was characterized. This site was confirmed to be heritable from the pedigree analyses of two families. Its expression was induced by AT-specific DNA-ligands: distamycin A, Hoechst 33258, berenil and DAPI, but not in M-F10-, BrdU- and control-cultures. The incidence has already been evaluated to be 0.71% (6/845) in a healthy population (Takahashi et al. 1987). Thus, a fragile 8q24.1 in the present study can be classified into the rare heritable distamycin A-inducible site.