由放线菌素A诱导的8号染色体上新的可遗传脆性位点。

New heritable fragile site on chromosome 8 induced by distamycin A.

作者信息

Ochi H, Watanabe S, Yamamoto H

机构信息

Epidemiology Division, National Cancer Center Research Institute, Tokyo.

出版信息

Jpn J Cancer Res. 1988 Feb;79(2):145-7. doi: 10.1111/j.1349-7006.1988.tb01568.x.

DOI:10.1111/j.1349-7006.1988.tb01568.x

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5917470/

Abstract

A possible new heritable fragile site at band 8q24.1, which is known to be a breakpoint in various cancers and contains the c-myc locus, was found in the lymphocytes from a woman with mastopathy. This fragile site was induced by distamycin A treatment, and expressed as gaps and breaks in 18% of the metaphases examined. The lymphocytes from one of her two sons examined also revealed gaps or breaks at the same site of chromosome 8 in 34% of the metaphases. This fragile 8q24.1 band is considered to be a new heritable fragile site induced by distamycin A.

摘要

在一位患有乳腺病的女性的淋巴细胞中发现了一个可能位于8q24.1带的新的可遗传脆性位点，已知该位点是多种癌症的断点且包含c-myc基因座。这个脆性位点是由放线菌素A处理诱导产生的，在所检查的中期相中，有18%表现为间隙和断裂。在她两个儿子中，有一个儿子的淋巴细胞在所检查的中期相中，也有34%在8号染色体的同一位置出现间隙或断裂。这个8q24.1脆性带被认为是由放线菌素A诱导产生的一个新的可遗传脆性位点。

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引用本文的文献

1

Induction of distamycin A-inducible rare fragile sites and increased sister chromatid exchanges at the fragile site.放线菌素A诱导稀有脆性位点的产生以及脆性位点处姐妹染色单体交换增加。

Hum Genet. 1991 Jul;87(3):254-60. doi: 10.1007/BF00200900.

本文引用的文献

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Demonstration of a heritable fragile site in human chromosome 16 with distamycin A.

Cytogenet Cell Genet. 1980;28(1-2):87-94. doi: 10.1159/000131516.

2

Two human c-onc genes are located on the long arm of chromosome 8.两个人类原癌基因位于8号染色体长臂上。

Proc Natl Acad Sci U S A. 1982 Dec;79(24):7842-6. doi: 10.1073/pnas.79.24.7842.

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The chromosomal basis of human neoplasia.人类肿瘤的染色体基础。

Science. 1983 Jul 15;221(4607):227-36. doi: 10.1126/science.6336310.

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Expression of cellular myc and mos genes in undifferentiated B cell lymphomas of Burkitt and non-Burkitt types.细胞myc和mos基因在伯基特型和非伯基特型未分化B细胞淋巴瘤中的表达。

Proc Natl Acad Sci U S A. 1983 Apr;80(7):1947-50. doi: 10.1073/pnas.80.7.1947.

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Heritable fragile sites on human chromosomes I. Factors affecting expression in lymphocyte culture.人类染色体上的遗传性脆性位点。I. 影响淋巴细胞培养中表达的因素。

Am J Hum Genet. 1979 Mar;31(2):125-35.

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