HIV-1 感染者中的自身抗体及抗逆转录病毒疗法（ART）对此的影响。

Autoantibodies Among HIV-1 Infected Individuals and the Effect of Anti-Retroviral Therapy (ART) on It.

机构信息

Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.

Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.

出版信息

Curr HIV Res. 2021;19(3):277-285. doi: 10.2174/1570162X19666210217120337.

DOI:10.2174/1570162X19666210217120337

PMID:33596809

Abstract

BACKGROUND

Antiretroviral therapy (ART) has led to a decline in autoimmune diseases but lacks studies on its effect on autoantibodies.

METHODS

It is a cross-sectional study with archived samples from 100 paired HIV-1 infected ART naïve and experienced individuals and 100 prospectively collected matched blood-donor controls. Antinuclear antibody, IgG anticardiolipin antibody, IgM and IgG β2 glycoprotein-1 antibodies, and total IgG levels were detected. Results are expressed as mean with standard deviation (SD), median, percentage positivity, and a p<0.05 is considered significant. The study was approved by the Institutional Review Board.

RESULTS

The median viral load of the treatment naïve samples was 4.34 Log copies/mL, while all were virally suppressed post ART with a median duration of treatment for 12 months (range: 3-36 months). The percentage of antinuclear antibody positivity was 5% among ART naïve and controls, with a decrease of 2% post ART (p= 0.441). The positivity for anti-cardiolipin antibody was 15% among ART naïve while none of the ART experienced or controls were positive (p<0.05). IgM β2 glycoprotein-1 were 4%, 1% and 3% among ART naïve, treated and controls, respectively (p<0.05). IgG β2 glycoprotein-1 was 2% among ART naïve while none of the treated and controls were positive (p<0.05). The mean total IgG level among ART naïve, experienced, and controls were 21.82 (SD 6.67), 16.91 (SD 3.38), 13.70 (SD 2.24) grams/Litre, respectively (p<0.05).

CONCLUSION

ART has a significant effect on IgG anti-cardiolipin antibody and total IgG but only a marginal effect on ANA, IgM, and IgG β2 glycoprotein-1 antibodies.

摘要

背景

抗逆转录病毒疗法（ART）已导致自身免疫性疾病的减少，但缺乏关于其对自身抗体影响的研究。

方法

这是一项横断面研究，使用了 100 对 HIV-1 感染的、未经 ART 治疗的和有经验的个体以及 100 例前瞻性采集的匹配献血者对照的存档样本。检测抗核抗体、IgG 抗心磷脂抗体、IgM 和 IgG β2 糖蛋白-1 抗体以及总 IgG 水平。结果表示为平均值±标准差（SD）、中位数、阳性百分比，p<0.05 被认为具有统计学意义。该研究得到了机构审查委员会的批准。

结果

未经 ART 治疗的样本的中位病毒载量为 4.34 Log 拷贝/mL，而所有样本在 ART 后均得到病毒抑制，中位治疗时间为 12 个月（范围：3-36 个月）。未经 ART 治疗的个体和对照组的抗核抗体阳性率为 5%，ART 治疗后下降了 2%（p=0.441）。未经 ART 治疗的个体抗心磷脂抗体阳性率为 15%，而无任何 ART 治疗的个体或对照组为阳性（p<0.05）。IgM β2 糖蛋白-1 在未经 ART 治疗的个体、治疗的个体和对照组中的阳性率分别为 4%、1%和 3%（p<0.05）。IgG β2 糖蛋白-1 在未经 ART 治疗的个体中为 2%，而无任何治疗的个体或对照组为阳性（p<0.05）。未经 ART 治疗、有经验的治疗和对照组的平均总 IgG 水平分别为 21.82（SD 6.67）、16.91（SD 3.38）和 13.70（SD 2.24）克/升（p<0.05）。