Department of Clinical Virology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.
Department of Clinical Microbiology, Christian Medical College, Vellore, Tamil Nadu, 632004, India.
Curr HIV Res. 2021;19(3):277-285. doi: 10.2174/1570162X19666210217120337.
Antiretroviral therapy (ART) has led to a decline in autoimmune diseases but lacks studies on its effect on autoantibodies.
It is a cross-sectional study with archived samples from 100 paired HIV-1 infected ART naïve and experienced individuals and 100 prospectively collected matched blood-donor controls. Antinuclear antibody, IgG anticardiolipin antibody, IgM and IgG β2 glycoprotein-1 antibodies, and total IgG levels were detected. Results are expressed as mean with standard deviation (SD), median, percentage positivity, and a p<0.05 is considered significant. The study was approved by the Institutional Review Board.
The median viral load of the treatment naïve samples was 4.34 Log copies/mL, while all were virally suppressed post ART with a median duration of treatment for 12 months (range: 3-36 months). The percentage of antinuclear antibody positivity was 5% among ART naïve and controls, with a decrease of 2% post ART (p= 0.441). The positivity for anti-cardiolipin antibody was 15% among ART naïve while none of the ART experienced or controls were positive (p<0.05). IgM β2 glycoprotein-1 were 4%, 1% and 3% among ART naïve, treated and controls, respectively (p<0.05). IgG β2 glycoprotein-1 was 2% among ART naïve while none of the treated and controls were positive (p<0.05). The mean total IgG level among ART naïve, experienced, and controls were 21.82 (SD 6.67), 16.91 (SD 3.38), 13.70 (SD 2.24) grams/Litre, respectively (p<0.05).
ART has a significant effect on IgG anti-cardiolipin antibody and total IgG but only a marginal effect on ANA, IgM, and IgG β2 glycoprotein-1 antibodies.
抗逆转录病毒疗法（ART）已导致自身免疫性疾病的减少，但缺乏关于其对自身抗体影响的研究。
这是一项横断面研究，使用了 100 对 HIV-1 感染的、未经 ART 治疗的和有经验的个体以及 100 例前瞻性采集的匹配献血者对照的存档样本。检测抗核抗体、IgG 抗心磷脂抗体、IgM 和 IgG β2 糖蛋白-1 抗体以及总 IgG 水平。结果表示为平均值±标准差（SD）、中位数、阳性百分比，p<0.05 被认为具有统计学意义。该研究得到了机构审查委员会的批准。
未经 ART 治疗的样本的中位病毒载量为 4.34 Log 拷贝/mL，而所有样本在 ART 后均得到病毒抑制，中位治疗时间为 12 个月（范围：3-36 个月）。未经 ART 治疗的个体和对照组的抗核抗体阳性率为 5%，ART 治疗后下降了 2%（p=0.441）。未经 ART 治疗的个体抗心磷脂抗体阳性率为 15%，而无任何 ART 治疗的个体或对照组为阳性（p<0.05）。IgM β2 糖蛋白-1 在未经 ART 治疗的个体、治疗的个体和对照组中的阳性率分别为 4%、1%和 3%（p<0.05）。IgG β2 糖蛋白-1 在未经 ART 治疗的个体中为 2%，而无任何治疗的个体或对照组为阳性（p<0.05）。未经 ART 治疗、有经验的治疗和对照组的平均总 IgG 水平分别为 21.82（SD 6.67）、16.91（SD 3.38）和 13.70（SD 2.24）克/升（p<0.05）。
ART 对 IgG 抗心磷脂抗体和总 IgG 有显著影响，但对 ANA、IgM 和 IgG β2 糖蛋白-1 抗体只有轻微影响。
