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本文引用的文献

1
Efficacy and safety of pharmacological treatments for patent ductus arteriosus closure: A systematic review and network meta-analysis of clinical trials and observational studies.药物治疗动脉导管未闭闭合的疗效和安全性：临床试验和观察性研究的系统评价和网络荟萃分析。
Pharmacol Res. 2019 Oct;148:104418. doi: 10.1016/j.phrs.2019.104418. Epub 2019 Aug 31.
2
Paracetamol in Patent Ductus Arteriosus Treatment: Efficacious and Safe?对乙酰氨基酚用于动脉导管未闭治疗：有效且安全吗？
Biomed Res Int. 2017;2017:1438038. doi: 10.1155/2017/1438038. Epub 2017 Jul 30.
3
Comparative study of the efficacy and safety of paracetamol, ibuprofen, and indomethacin in closure of patent ductus arteriosus in preterm neonates.对乙酰氨基酚、布洛芬和吲哚美辛在早产儿动脉导管未闭封堵中的疗效和安全性比较研究。
Eur J Pediatr. 2017 Feb;176(2):233-240. doi: 10.1007/s00431-016-2830-7. Epub 2016 Dec 21.
4
Patent Ductus Arteriosus in the Preterm Infant: Diagnostic and Treatment Options.早产儿动脉导管未闭：诊断与治疗选择
Adv Neonatal Care. 2017 Feb;17(1):10-18. doi: 10.1097/ANC.0000000000000340.
5
Paracetamol Accelerates Closure of the Ductus Arteriosus after Premature Birth: A Randomized Trial.对乙酰氨基酚可加速早产儿动脉导管闭合：一项随机试验。
J Pediatr. 2016 Oct;177:72-77.e2. doi: 10.1016/j.jpeds.2016.04.066. Epub 2016 May 20.
6
Oral medications regarding their safety and efficacy in the management of patent ductus arteriosus.关于口服药物在动脉导管未闭治疗中的安全性和有效性。
World J Clin Pediatr. 2016 Feb 8;5(1):75-81. doi: 10.5409/wjcp.v5.i1.75.
7
Patent Ductus Arteriosus in Preterm Infants.早产儿动脉导管未闭
Pediatrics. 2016 Jan;137(1). doi: 10.1542/peds.2015-3730. Epub 2015 Dec 15.
8
Cardiovascular disease and type 1 diabetes: prevalence, prediction and management in an ageing population.心血管疾病与1型糖尿病：老年人群中的患病率、预测及管理
Ther Adv Chronic Dis. 2015 Nov;6(6):347-74. doi: 10.1177/2040622315598502.
9
Paracetamol for the treatment of patent ductus arteriosus in preterm neonates: a systematic review and meta-analysis.对乙酰氨基酚用于治疗早产儿动脉导管未闭：一项系统评价和荟萃分析。
Arch Dis Child Fetal Neonatal Ed. 2016 Mar;101(2):F127-36. doi: 10.1136/archdischild-2014-307312. Epub 2015 Aug 17.
10
Enteral paracetamol or Intravenous Indomethacin for Closure of Patent Ductus Arteriosus in Preterm Neonates: A Randomized Controlled Trial.肠内给予对乙酰氨基酚或静脉注射吲哚美辛用于早产儿动脉导管未闭的闭合：一项随机对照试验。
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高剂量静脉用对乙酰氨基酚是否会影响早产儿动脉导管未闭关闭时的肝功能？

Does high dose intravenous acetaminophen affect liver function for PDA closure in premature neonate?

机构信息

Neonatal Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Department of Pediatrics, Division of Pediatric Cardiology, Nemazee Hospital, Shiraz University of Medical Sciences, Shiraz, 7193711351, Iran.

出版信息

Ital J Pediatr. 2021 Feb 18;47(1):37. doi: 10.1186/s13052-020-00940-2.

DOI:10.1186/s13052-020-00940-2
PMID:33596978
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7890839/
Abstract

OBJECTIVES

The aim of this study was to collect consistent data on the efficacy and safety and evaluation hepatotoxicity of intravenous acetaminophen for the treatment of PDA in preterm infants.

METHODS

This is an observational longitudinal prospective study on 46 preterm infants with PDA who treated with high dose of acetaminophen and evaluated with echocardiography and serum liver enzymes at Hafez and Zeinabiyeh hospitals from January 2016 to December 2019.

RESULT

Forty-six preterm infants with PDA treated with intravenous acetaminophen. Rate of closure of PDA was 82.6. There was no significant difference after treatment regarding AST, ALT, Albumin, total and direct bilirubin (P value > 0.05) and no adverse side effects were observed in association with intravenous acetaminophen.

CONCLUSION

High dose of acetaminophen is not more effective than that with standard doses although without hepatotoxic side effect for PDA closure.

摘要

目的

本研究旨在收集关于静脉用对乙酰氨基酚治疗早产儿动脉导管未闭（PDA）的疗效和安全性数据，并评估其对肝脏的毒性。

方法

这是一项对 2016 年 1 月至 2019 年 12 月在 Hafez 和 Zeinabiyeh 医院接受大剂量对乙酰氨基酚治疗的 46 例 PDA 早产儿进行的观察性纵向前瞻性研究，通过超声心动图和血清肝酶进行评估。

结果

46 例 PDA 早产儿接受了静脉用对乙酰氨基酚治疗。PDA 关闭率为 82.6%。治疗后，AST、ALT、白蛋白、总胆红素和直接胆红素无显著差异（P 值>0.05），且未观察到与静脉用对乙酰氨基酚相关的不良反应。

结论

尽管大剂量对乙酰氨基酚在 PDA 关闭方面没有肝毒性副作用，但并不比标准剂量更有效。