Department of Blood Transfusion, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China.
Department of Radiology, the First Hospital of Jilin University, Changchun, Jilin, China.
Sci Rep. 2021 Feb 17;11(1):3990. doi: 10.1038/s41598-021-83149-5.
We aimed to explore the clinicopathological features and survival-related factors for intrahepatic cholangiocarcinoma (ICC). Eligible data were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 2004 to 2015. Totally, 4595 ICC patients were collected with a male to female ratio of nearly 1:1. The higher proportion of ICC patients was elderly, tumor size ≥ 5 cm and advanced AJCC stage. Most patients (79.2%) have no surgery, while low proportion of patients receiving radiotherapy (15.1%). The median survival was 7.0 months (range 0-153 months). The 5-year CSS and OS rates were 8.96% and 7.90%. Multivariate analysis found that elderly age (aged ≥ 65 years old), male, diagnosis at 2008-2011, higher grade, tumor size ≥ 5 cm, and advanced AJCC stage were independent factors for poorer prognosis; while API/AI (American Indian/AK Native, Asian/Pacific Islander) race, married, chemotherapy, surgery and radiotherapy were independent favorable factors in both CSS and OS. Furthermore, stratified analysis found that chemotherapy and radiotherapy improved CSS and OS in patients without surgery. Age, sex, race, years of diagnosis, married status, grade, tumor size, AJCC stage, surgery, chemotherapy and radiotherapy were significantly related to prognosis of ICC. Chemotherapy and radiotherapy could significantly improve survival in patients without surgery.
我们旨在探讨肝内胆管癌（ICC）的临床病理特征和与生存相关的因素。合格数据从 2004 年至 2015 年从监测、流行病学和最终结果（SEER）数据库中提取。共收集了 4595 例 ICC 患者，男女比例接近 1:1。ICC 患者中高龄、肿瘤大小≥5cm 和 AJCC 晚期的比例较高。大多数患者（79.2%）未接受手术，而接受放疗的患者比例较低（15.1%）。中位生存期为 7.0 个月（范围 0-153 个月）。5 年 CSS 和 OS 率分别为 8.96%和 7.90%。多因素分析发现，年龄较大（≥65 岁）、男性、2008-2011 年诊断、较高分级、肿瘤大小≥5cm 和 AJCC 晚期是预后较差的独立因素；而 API/AI（美国印第安人/阿拉斯加原住民、亚洲/太平洋岛民）种族、已婚、化疗、手术和放疗是 CSS 和 OS 的独立有利因素。此外，分层分析发现，化疗和放疗改善了未手术患者的 CSS 和 OS。年龄、性别、种族、诊断年限、婚姻状况、分级、肿瘤大小、AJCC 分期、手术、化疗和放疗与 ICC 的预后显著相关。化疗和放疗可显著改善未手术患者的生存。
