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波兰国家经皮冠状动脉介入治疗注册中心的五年报告,重点关注慢性完全闭塞病变中的冠状动脉穿孔。

Five-year report from the Polish national registry on percutaneous coronary interventions with a focus on coronary artery perforations within chronic total occlusions.

作者信息

Januszek Rafał, Bryniarski Leszek, Siudak Zbigniew, Malinowski Krzysztof P, Bryniarski Krzysztof L, Surdacki Andrzej, Dziewierz Artur, Mika Piotr, Wańha Wojciech, Wojakowski Wojciech, Wójcik Jarosław, Legutko Jacek, Bartuś Stanisław

机构信息

Department of Cardiology and Cardiovascular Interventions, University Hospital, Krakow, Poland.

Department of Clinical Rehabilitation, University School of Physical Education, Krakow, Poland.

出版信息

Postepy Kardiol Interwencyjnej. 2020 Dec;16(4):399-409. doi: 10.5114/aic.2020.101764. Epub 2020 Dec 29.

Abstract

INTRODUCTION

Patients treated within chronic total occlusions (CTO) using percutaneous coronary intervention (PCI) are at increased risk of periprocedural complications.

AIM

To assess the frequency of periprocedural complications with particular emphasis on coronary artery perforations (CAPs) among patients treated with PCIs stratified according to CTOs and their predictors.

MATERIAL AND METHODS

Based on a nationwide registry (ORPKI), we analysed 535,853 patients treated with PCI between 2014 and 2018. The study included 12,572 (2.34%) patients treated with CTO PCI. We compared CTO PCI to a non-CTO PCI group before and after propensity score matching (PSM). Multifactorial mixed regression models were used to assess predictors of periprocedural complications and CAPs which occurred within the catheterization laboratory.

RESULTS

Frequencies of all periprocedural complications (2.75% vs. 1.93%, < 0.001) and CAP (0.72% vs. 0.16%, < 0.001) were significantly higher in the CTO PCI group. Multifactorial regression analysis performed in the all-comers group of patients treated with PCI showed that PCI within CTO was related to a higher CAP rate (odds ratio (OR) = 2.18; 95% confidence interval (CI): 1.68-2.82, < 0.001). After PSM, we extracted 5,652 patients treated within CTO and 5,652 patients with non-CTO PCI. CTO PCI was also related to a higher frequency of CAPs (OR = 1.89; 95% CI: 1.11-3.31, = 0.01).

CONCLUSIONS

The frequency of periprocedural complications and CAPs remained stable during the assessed period of time. CTO PCI was confirmed to be among the predictors of increased CAP rate in the overall group of patients treated within CTO.

摘要

引言

采用经皮冠状动脉介入治疗(PCI)处理慢性完全闭塞病变(CTO)的患者围手术期并发症风险增加。

目的

评估围手术期并发症的发生率,特别关注根据CTO及其预测因素分层的PCI治疗患者中的冠状动脉穿孔(CAP)情况。

材料与方法

基于全国性注册研究(ORPKI),我们分析了2014年至2018年间接受PCI治疗的535853例患者。该研究纳入了12572例(2.34%)接受CTO PCI治疗的患者。我们在倾向评分匹配(PSM)前后将CTO PCI组与非CTO PCI组进行了比较。采用多因素混合回归模型评估导管室发生的围手术期并发症和CAP的预测因素。

结果

CTO PCI组所有围手术期并发症(2.75%对1.93%,P<0.001)和CAP(0.72%对0.16%,P<0.001)的发生率显著更高。在接受PCI治疗的所有患者全人群组中进行的多因素回归分析显示,CTO内的PCI与更高的CAP发生率相关(优势比(OR)=2.18;95%置信区间(CI):1.68 - 2.82,P<0.001)。PSM后,我们提取了5652例接受CTO治疗的患者和5652例接受非CTO PCI治疗的患者。CTO PCI也与更高的CAP发生率相关(OR = 1.89;95% CI:1.11 - 3.31,P = 0.01)。

结论

在评估时间段内,围手术期并发症和CAP的发生率保持稳定。CTO PCI被证实是CTO治疗的总体患者组中CAP发生率增加的预测因素之一。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b1e/7863825/15892a8989a2/PWKI-16-42700-g001.jpg

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