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伪装成脑膜炎的颅底凹陷性齿状突综合征

Crowned Dens Syndrome Masquerading as Meningitis.

作者信息

Bamgboje Abayomi O, Mohandas Nirupa

机构信息

Internal Medicine, New York City Health + Hospitals/Metropolitan, New York, USA.

Internal Medicine/Rheumatology, New York City Health + Hospitals/Metropolitan, New York, USA.

出版信息

Cureus. 2021 Jan 13;13(1):e12678. doi: 10.7759/cureus.12678.

DOI:10.7759/cureus.12678
PMID:33598372
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7880003/
Abstract

The classic symptoms of meningismus, including fever, neck stiffness, and headache, should automatically trigger a prime differential of meningitis, but a close masquerader, albeit rare, is crowned dens syndrome. Herein, we report the case of a 71-year-old woman with clinical features of meningismus with elevated inflammatory biomarkers. However, computed tomography of the cervical spine revealed the presence of calcium deposits encircling the dens. Hence, an alternate diagnosis of crowned dens syndrome was considered. This was confirmed by the presence of similar pathology in other joints and the dramatic resolution of symptoms and inflammatory markers with the administration of nonsteroidal anti-inflammatory drugs.

摘要

脑膜刺激征的典型症状,包括发热、颈部僵硬和头痛,应自动引发对脑膜炎的主要鉴别诊断,但有一种虽罕见但酷似的病症是齿状突综合征。在此,我们报告一例71岁女性病例,其具有脑膜刺激征的临床特征且炎症生物标志物升高。然而,颈椎计算机断层扫描显示齿状突周围存在钙沉积。因此,考虑为齿状突综合征的另一种诊断。其他关节存在类似病变以及使用非甾体抗炎药后症状和炎症标志物显著缓解证实了这一诊断。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367d/7880003/db8dc08bc2de/cureus-0013-00000012678-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367d/7880003/553f442e4be0/cureus-0013-00000012678-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367d/7880003/b823209cd4d5/cureus-0013-00000012678-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367d/7880003/db8dc08bc2de/cureus-0013-00000012678-i03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367d/7880003/553f442e4be0/cureus-0013-00000012678-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367d/7880003/b823209cd4d5/cureus-0013-00000012678-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/367d/7880003/db8dc08bc2de/cureus-0013-00000012678-i03.jpg

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Crowned Dens Syndrome Masquerading as Meningitis.伪装成脑膜炎的颅底凹陷性齿状突综合征
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本文引用的文献

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A Case of Acute Neck Pain: The Crowned Dens Syndrome.一例急性颈部疼痛:齿突冠突综合征。
Cureus. 2020 Aug 4;12(8):e9555. doi: 10.7759/cureus.9555.
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Cervical CT-Dependent Diagnosis of Crowned Dens Syndrome in Calcium Pyrophosphate Dihydrate Crystal Deposition Disease.颈椎 CT 依赖性诊断焦磷酸钙二水化合物晶体沉积病中的冠状突综合征。
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Inflammasome activation and assembly at a glance.炎症小体激活与组装速览。
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Interleukin-1 function and role in rheumatic disease.白细胞介素-1 的功能及其在风湿性疾病中的作用。
Nat Rev Rheumatol. 2016 Jan;12(1):14-24. doi: 10.1038/nrrheum.2016.166. Epub 2015 Dec 10.
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Calcium pyrophosphate deposition disease: a review of epidemiologic findings.焦磷酸钙沉积病:流行病学研究结果综述
Curr Opin Rheumatol. 2016 Mar;28(2):133-9. doi: 10.1097/BOR.0000000000000246.
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Crowned Dens Syndrome: Report of Three Cases and a Review of the Literature.颅底凹陷综合征:三例报告及文献复习
J Emerg Med. 2015 Jul;49(1):e9-e13. doi: 10.1016/j.jemermed.2015.02.005. Epub 2015 Apr 21.
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Eighteen cases of crowned dens syndrome: Presentation and diagnosis.18例颅底凹陷综合征:临床表现与诊断
Neurochirurgie. 2013 Jun;59(3):115-20. doi: 10.1016/j.neuchi.2013.03.003. Epub 2013 Jun 24.
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Crowned dens syndrome: a rare cause of acute neck pain.冠突窝综合征:一种导致急性颈痛的罕见病因。
Clin Rheumatol. 2013 May;32(5):711-4. doi: 10.1007/s10067-013-2179-5. Epub 2013 Feb 8.
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Evidence of a systemic predisposition to chondrocalcinosis and association between chondrocalcinosis and osteoarthritis at distant joints: a cross-sectional study.存在全身性易患软骨钙质沉着症的证据,以及软骨钙质沉着症与远处关节骨关节炎之间的关联:一项横断面研究。
Arthritis Care Res (Hoboken). 2013 Jul;65(7):1052-8. doi: 10.1002/acr.21952.