Saku Kosuke, Tahara Nobuhiro, Fukumoto Yoshihiro, Tanaka Hiroyuki
Department of Surgery, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Division of Cardiovascular Medicine, Department of Medicine, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Eur Heart J Case Rep. 2020 Dec 16;5(2):ytaa517. doi: 10.1093/ehjcr/ytaa517. eCollection 2021 Feb.
Hepatocellular carcinoma (HCC) that metastasizes to the right ventricle has rarely been reported. An important link between epithelial-mesenchymal transition (EMT) and the invasion and metastasis of cancer cells has recently been demonstrated. However, there are few reports on the relationship between HCC metastasized to the heart and EMT.
We here report the case of a 74-year-old woman who had type C HCC referred to our hospital with general fatigue due to a right ventricular tumour diagnosed at a general hospital. Anticoagulation therapy was done, but the mass had rapidly grown. We performed surgical resection of the mass. Histopathological examination revealed that the tumour was diagnosed as a poorly differentiated HCC metastasis induced by EMT.
Isolated metastasis of HCC to the right ventricle is extremely rare. The HCC with EMT has a potentially high risk of metastasizing to the heart and other organs, and the prognosis is poor.
肝细胞癌（HCC）转移至右心室的情况鲜有报道。上皮-间质转化（EMT）与癌细胞侵袭和转移之间的重要联系最近已得到证实。然而，关于转移至心脏的HCC与EMT之间关系的报道较少。
我们在此报告一例74岁女性，因在综合医院诊断出右心室肿瘤导致全身乏力，被转诊至我院，其患有C型HCC。已进行抗凝治疗，但肿块迅速增大。我们对肿块进行了手术切除。组织病理学检查显示，该肿瘤被诊断为由EMT诱导的低分化HCC转移。
HCC孤立转移至右心室极为罕见。伴有EMT的HCC转移至心脏和其他器官的潜在风险较高，且预后较差。
