Raab R, Werner U, Löhlein D
Klinik für Abdominal- und Transplantationschirurgie, Medizinischen Hochschule Hannover.
Chirurg. 1988 Feb;59(2):96-100.
In our own patient population with primary colorectal cancer (n = 1352, 1971-1984) we analyzed the frequency, characteristics and prognosis of multiple carcinomas. The overall incidence was 7.3% (4.5% synchronous and 2.8% metachronous carcinomas). Compared to single cancer synchronous tumors had a worse and metachronous tumors had a better 5 year-prognosis (58%, 43% and 86% respectively). This suggests that synchronous and metachronous colorectal carcinomas may be two biologically separate entities. Conclusions from our observations are discussed in regard to diagnosis, therapy and follow-up.
