Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Department of Clinical Laboratory Center, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin, 300052, China.
Neurol Sci. 2021 Oct;42(10):4249-4255. doi: 10.1007/s10072-021-05108-2. Epub 2021 Feb 17.
Beta-2-microglobulin (β2-MG) levels vary in many infectious and autoimmune diseases. We investigated plasma and cerebrospinal fluid (CSF) β2-MG levels in patients with Guillain-Barré syndrome (GBS) and their correlations with clinical parameters.
CSF samples from 50 patients with GBS including 19 acute inflammatory demyelinating polyneuropathy (AIDP), 6 acute motor axonal neuropathy (AMAN), 10 acute motor-sensory axonal neuropathy (AMSAN), 7 Miller-Fisher syndrome (MFS), and 8 unclassified patients were collected. Moreover, 23 CSF samples from patients with non-inflammatory neurological disorders (NIND) as controls were collected. Plasma samples from 42 enrolled patients and 29 healthy individuals were also collected. The β2-MG levels were measured by immunoturbidimetry on automatic biochemical analyser. Besides, clinical data were extracted from electronic patient documentation system.
CSF levels of β2-MG, lactate dehydrogenase (LDH), and lactate were significantly increased in patients with GBS (p = 0.004, p = 0.041, p = 0.040, respectively), particularly in patients with AIDP (p < 0.001, p = 0.001, p = 0.015, respectively), whereas no statistically significant difference was found in plasma levels of β2-MG. Furthermore, CSF levels of β2-MG were positively correlated with Hughes functional score (r = 0.493, p = 0.032), LDH (r = 0.796, p < 0.001), and lactate (r = 0.481, p = 0.037) but not with protein (r = - 0.090, p = 0.713) in AIDP patients.
CSF β2-MG levels may help identify AIDP and indicate clinical severity. CSF LDH and lactate levels correlate with CSF β2-MG levels; interaction among these biomarkers would need further investigation.
β2-微球蛋白（β2-MG）水平在许多感染性和自身免疫性疾病中会发生变化。我们研究了吉兰-巴雷综合征（GBS）患者的血浆和脑脊液（CSF）β2-MG 水平及其与临床参数的相关性。
收集了 50 例 GBS 患者的 CSF 样本，包括 19 例急性炎症性脱髓鞘性多发性神经病（AIDP）、6 例急性运动轴索性神经病（AMAN）、10 例急性运动感觉轴索性神经病（AMSAN）、7 例米勒-费舍尔综合征（MFS）和 8 例未分类患者。此外，还收集了 23 例非炎症性神经疾病（NIND）患者的 CSF 样本作为对照。还收集了 42 名入组患者和 29 名健康个体的血浆样本。β2-MG 水平通过自动生化分析仪的免疫比浊法进行测量。此外，从电子患者文档系统中提取临床数据。
GBS 患者的 CSF 中β2-MG、乳酸脱氢酶（LDH）和乳酸水平显著升高（p = 0.004、p = 0.041、p = 0.040，分别），尤其是 AIDP 患者（p < 0.001、p = 0.001、p = 0.015，分别），而血浆中β2-MG 水平无统计学差异。此外，AIDP 患者的 CSF 中β2-MG 水平与 Hughes 功能评分（r = 0.493，p = 0.032）、LDH（r = 0.796，p < 0.001）和乳酸（r = 0.481，p = 0.037）呈正相关，但与蛋白（r = - 0.090，p = 0.713）无相关性。
CSFβ2-MG 水平可能有助于识别 AIDP 并指示临床严重程度。CSF LDH 和乳酸水平与 CSFβ2-MG 水平相关；这些生物标志物之间的相互作用需要进一步研究。
