多发性硬化症患者的年龄校正 CSF β2-微球蛋白和乳酸升高，ACE 降低，但只有乳酸与临床疾病持续时间和严重程度相关。

Age-adjusted CSF β2-microglobulin and lactate are increased and ACE is decreased in patients with multiple sclerosis, but only lactate correlates with clinical disease duration and severity.

机构信息

Department of Neurology, University of Würzburg, Würzburg, Germany.

Department of Neurology, University of Würzburg, Würzburg, Germany; Department of Neurology, Caritas Hospital, Bad Mergentheim, Germany.

出版信息

J Neuroimmunol. 2018 Oct 15;323:19-27. doi: 10.1016/j.jneuroim.2018.07.001. Epub 2018 Jul 4.

DOI:10.1016/j.jneuroim.2018.07.001

PMID:30196829

Abstract

We compared cerebrospinal fluid levels of lactate, β2-microglobulin and angiotensin-converting enzyme (ACE) between 438 untreated patients with multiple sclerosis and 276 patients with non-inflammatory neurological disorders. Age-adjusted β2-microglobulin and lactate were significantly higher and ACE was significantly lower in MS patients than in controls. β2-microglobulin and ACE positively correlated with high significance both in MS patients and controls. While disease duration negatively correlated and progression index, defined as EDSS score divided by disease duration in years, positively correlated with age-adjusted lactate levels, both did neither correlate with β2-microglobulin nor with ACE. Both CSF β2-microglobulin and ACE deserve further investigation as biomarkers of multiple sclerosis pathophysiology.

摘要

我们比较了 438 名未经治疗的多发性硬化症患者和 276 名非炎症性神经疾病患者的脑脊液中乳酸、β2-微球蛋白和血管紧张素转换酶（ACE）的水平。校正年龄后，多发性硬化症患者的β2-微球蛋白和乳酸明显升高，ACE 明显降低。β2-微球蛋白和 ACE 在多发性硬化症患者和对照组中均呈显著正相关。而疾病持续时间与校正年龄后的乳酸水平呈负相关，进展指数（定义为 EDSS 评分除以疾病持续时间的年数）与校正年龄后的乳酸水平呈正相关，这两者均与β2-微球蛋白或 ACE 无关。CSFβ2-微球蛋白和 ACE 均值得进一步研究，作为多发性硬化症病理生理学的生物标志物。