Kauffman H M, Sampson D, Fox P S, Stawicki A T
Ann Surg. 1977 Nov;186(5):631-4. doi: 10.1097/00000658-197711000-00015.
A completely randomized double-blind study of bolus methylprednisolone versus dextrose in water, administered at the time of human kidney transplantation, has failed to demonstrate any beneficial effect of the steroid therapy. No differences were observed in the number of complete, irreversible graft rejections, the number of acute rejection episodes, or the number of postoperative steroid boluses administered in the treated or the control groups. Similarly, there were no differences in the mean serum creatinines at 30, 60, 90 days post-transplantation. There was a slight increase in mortality and incidence of complications in the group of patients receiving an intravenous bolus of methylprednisolone at the time of transplantation as compared to controls. The failure to demonstrate any beneficial effect and the slight increased mortality and morbidity associated with the bolus methylprednisolone dosage makes this therapy unjustifiable.
一项关于在人类肾脏移植时给予大剂量甲基强的松龙与静脉输注葡萄糖的完全随机双盲研究，未能证明类固醇疗法有任何有益效果。在治疗组或对照组中，完全不可逆移植排斥的数量、急性排斥发作的数量或术后给予类固醇大剂量冲击治疗的次数均未观察到差异。同样，移植后30天、60天、90天的平均血清肌酐水平也没有差异。与对照组相比，在移植时接受静脉注射大剂量甲基强的松龙的患者组死亡率和并发症发生率略有增加。未能证明有任何有益效果以及与大剂量甲基强的松龙剂量相关的死亡率和发病率略有增加，使得这种治疗方法不合理。
