Zhao Qian-Kun, Wu Xiong, Li Lin-Ping, Yang Fan, Xie Jian-Hua, Zhou Qi-Lin
State Key Laboratory and Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.
Org Lett. 2021 Mar 5;23(5):1675-1680. doi: 10.1021/acs.orglett.1c00093. Epub 2021 Feb 18.
Herein, we report a practical method for efficient asymmetric hydrogenation of β-aryl alkylidene malonates. With a site-specifically tailored chiral spiro iridium catalyst, a series of β-aryl alkylidene malonate esters were hydrogenated to afford chiral malonate esters with good to excellent enantioselectivities (up to 99% ee) and high turnover numbers (up to 19000). The results showed that installing an ester group in α,β-unsaturated carboxylic esters significantly increased the efficiency of their asymmetric hydrogenation reactions.
在此，我们报道了一种用于高效不对称氢化β-芳基亚烷基丙二酸酯的实用方法。使用位点特异性定制的手性螺环铱催化剂，一系列β-芳基亚烷基丙二酸酯被氢化，以提供对映选择性良好至优异（高达99% ee）且高周转数（高达19000）的手性丙二酸酯。结果表明，在α,β-不饱和羧酸酯中引入酯基显著提高了它们的不对称氢化反应效率。
