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[华氏巨球蛋白血症中的肾脏受累——病例报告]

[Kidney involvement in Waldenström's disease - case report].

作者信息

Fomasi Luigi, Foini Paolo, Marchi Gianluca, Ghiringhelli Paolo, Molteni Alfredo, Ungari Marco, Fisogni Simona, Malberti Fabio

机构信息

UO Nefrologia e Dialisi ASST Spedali civili di Brescia - Scuola di specializzazione in Nefrologia di Brescia, Italia.

UO Nefrologia e Dialisi ASST Cremona, Italia.

出版信息

G Ital Nefrol. 2021 Feb 16;38(1):2021-vol1.

Abstract

Waldenström's disease is a rare haematological neoplasm involving B lymphocytes, characterized by medullary infiltrated lymphoplasmacytic lymphoma and by the presence of a monoclonal M paraprotein. Although rarely, this condition may lead to heterogeneous renal involvement and cause severe renal failure. We report the clinical case of a patient with overt nephrotic syndrome in Waldenström's disease treated with a combination chemotherapy (rituximab, cyclophosphamide, dexamethasone) until complete renal and haematological remission.

摘要

华氏巨球蛋白血症是一种罕见的累及B淋巴细胞的血液系统肿瘤,其特征为骨髓浸润性淋巴浆细胞淋巴瘤以及存在单克隆M蛋白。尽管罕见,但这种情况可能导致肾脏出现异质性受累并引起严重肾衰竭。我们报告了一例华氏巨球蛋白血症伴明显肾病综合征患者的临床病例,该患者接受了联合化疗(利妥昔单抗、环磷酰胺、地塞米松)治疗,直至肾脏和血液学完全缓解。

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