Harada Y, Ido N, Okada T, Otani M, Shirota T, Nakao T, Hayashi T
The Third Department of Internal Medicine, Tokyo Medical University Hospital, Tokyo, Japan.
Br J Haematol. 2000 Sep;110(4):880-3. doi: 10.1046/j.1365-2141.2000.02259.x.
Waldenström's macroglobulinaemia (WM) is described as a disorder of plasmacytoid lymphocytes. The renal complications of WM are less common and severe than those of multiple myeloma. We present a case of WM complicated by nephrotic syndrome. A biopsy specimen of the kidney revealed the intraglomerular thrombi of immunoglobulin M paraprotein. Corticosteroid pulse therapy and plasmapheresis were effective in improving proteinuria and reducing protein thrombi. The nephrotic syndrome caused by protein thrombi in WM may be reversible, at least in its early stage.
华氏巨球蛋白血症（WM）被描述为浆细胞样淋巴细胞的一种病症。WM的肾脏并发症比多发性骨髓瘤的并发症少见且严重程度更低。我们报告一例并发肾病综合征的WM病例。肾脏活检标本显示存在免疫球蛋白M副蛋白的肾小球内血栓。糖皮质激素冲击疗法和血浆置换术在改善蛋白尿和减少蛋白血栓方面有效。WM中由蛋白血栓引起的肾病综合征可能是可逆的，至少在其早期阶段如此。
