可分离的小分子半胱氨酸亚磺酸。
Isolable small-molecule cysteine sulfenic acid.
机构信息
Department of Chemistry, School of Science, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, 152-8551, Japan.
出版信息
Chem Commun (Camb). 2021 Mar 9;57(20):2479-2482. doi: 10.1039/d0cc08422k.
PMID:33599629
Abstract
An isolable small-molecule cysteine sulfenic acid (Cys-SOH) protected by a molecular cradle was synthesized by direct oxidation of the corresponding cysteine thiol and its structure was established by X-ray crystallographic analysis. Studies on biologically relevant reactivity indicated its usefulness as a biorepresentative small-molecule sulfenic acid model.
摘要
合成了一种小分子半胱氨酸亚磺酸（Cys-SOH），它由分子摇篮保护，通过相应的半胱氨酸巯基直接氧化得到，并通过 X 射线晶体结构分析确定了其结构。对生物相关反应性的研究表明，它可用作生物代表性小分子亚磺酸模型。
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